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Structure, Function and Regulation of TOR complexes from Yeasts to Mammals
Part A
In-depth reviews of our current knowledge of TOR complexes are discussed by the leaders in the field.
Michael N Hall (Volume editor), Fuyuhiko Tamanoi (Volume editor)
9780123815392, Elsevier Science
Hardback, published 15 May 2010
420 pages
22.9 x 15.1 x 2.7 cm, 0.68 kg
Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging. There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leaders in the field.
Chapter 1: TOR complexes: composition, structure and phosphorylation Mike Hall Chapter 2: Regulation of TOR signaling in mammals Dudley W. Lamming and David Sabatini Chapter 3: Rheb G-protein and activation of mTORC1 Fuyu Tamanoi Chapter 4: Regulation of TOR Complex1 by amino acids through small GTPases Joe Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, and Noriko Oshiro Chapter 5: Rag GTPases in TORC1 activation and nutrient signaling Li Li and Kun-Liang Guan Chapter 6: Amino Acid Regulation of hVps34 and mTORC1 signaling Pawan Gulati and George Thomas Chapter 7: mTORC1 and cell cycle control Chris Proud Chapter 8: AGC Kinases in mTOR Signaling Estela Jacinto Chapter 9: TORC1 signaling in budding yeast Robbie Loewith Chapter 10: TORC2 and sphingolipid biosynthesis and signaling: Lessons from budding yeast Ted Powers Chapter 11: TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungi Robert J. Bastidas and Maria Cardenas-Corona Chapter 12: TOR and sexual development in fission yeast Yoko Otsubo and Masayuki Yamamoto Chapter 13: Fission yeast TOR and rapamycin Ronit Weisman Chapter 14: Structure of TOR complexes in fission yeast Junko Kanoh and Mitsuhiro Yanagida Chapter 15: The TOR complex and signaling pathway in plants Christophe Robaglia, Bruce Veit and Christian Meyer Chapter 16: Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis Elizabeth Henske Chapter 17: Chemistry and Pharmacology of Rapamycin and its Derivatives Robert T. Abraham, James J. Gibbons and Edmund I. Graziani
Subject Areas: Animal physiology [PSVD], Immunology [MJCM], Physiology [MFG]
