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Structural Genomics, Part C
This volume presents step-by-step techniques for researchers that will predict the structure and potential function of proteins by identifying its coding sequence.
Andrzej Joachimiak (Volume editor)
9780123814432, Elsevier Science
Hardback, published 15 December 2009
96 pages
22.9 x 15.1 x 1.6 cm, 0.33 kg
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
Subject Areas: Molecular biology [PSD]
