Strategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis

Michael Harmata (Edited by)

9780123739032

Hardback, published 12 December 2007

536 pages
22.9 x 15.1 x 3.1 cm, 1 kg

"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike."
J. AM. CHEM. SOC, Vol. 128, no. 10, 2006

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

chapter 1 TOTAL SYNTHESIS OF RK-397TOTAL SYNTHESIS OF RK-397
chapter 2 A FORMAL TOTAL SYNTHESIS OF THE MARINE
DITERPENOID, DIISOCYANOADOCIANE
chapter 3 TOTAL SYNTHESES OF ZOAPATANOL
chapter 4 SYNTHESIS OF MOLECULAR TWEEZERS AND
CLIPS BY THE USE OF A MOLECULAR LEGO SET AND THEIR SUPRAMOLECULAR FUNCTIONS
chapter 5 APPLICATION OF C-GLYCOSIDES IN THE TOTAL SYNTHESIS OF (-)-GAMBIEROL
chapter 6 A BIOMIMETIC APPROACH TO THE OCAGLAMIDES EMPLOYING PHOTOGENERATION OF OXIDOPYRYLIUMS
DERIVED FROM 3-HYDROXYFLAVONES
chapter 7 SYNTHESIS STUDIES OF DOLABELLANES AND TRANSANNULAR PROCESSES LEADING TO RELATED DITERPENES
chapter 8 DIPHENYLOXAZINONES: VERSATILE TEMPLATES
FOR THE ASYMMETRIC SYNTHESIS OF ??-AMINO ACIDS, PEPTIDE ISOSTERES, AND NATURAL PRODUCTS
chapter 9 RHODIUM-CATALYZED CYCLOISOMERIZATION
REACTIONS OF ALLENES IN DIVERSITY-ORIENTED
SYNTHESIS
chapter 10 HYDROGEN-BOND-MEDIATED ORGANIC SYNTHESIS IN THE SOLID STATE
chapter 11 TOTAL SYNTHESES OF NATURAL PRODUCTS
USING THE COMBINED C??H ACTIVATION/COPE REARRANGEMENT AS THE KEY STEP
chapter 12 THE TOTAL SYNTHESIS OF AMPHIBIAN
ALKALOIDS USING THE INTRAMOLECULAR SCHMIDT REACTION
chapter 13 SEDUCED BY A SIREN’S CALL: EXPANDING
APPLICATIONS FOR AROMATIC COMPOUNDS AND THE SYNTHESIS OF (+)-RISHIRILIDE B

Subject Areas: Geochemistry [RBGK], Geology & the lithosphere [RBG], Organic chemistry [PNN], Chemistry [PN], Scientific equipment, experiments & techniques [PDN]