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Stem Cell Manufacturing
This timely book discusses the technologies that enable transfer of the laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while achieving control, reproducibility, automation, validation, and safety of process and product
Joaquim M.S. Cabral (Edited by), Claudia Lobato da Silva (Edited by), Lucas G. Chase (Edited by), M. Margardia Diogo (Edited by)
9780444632654, Elsevier Science
Hardback, published 25 July 2016
340 pages, 20 illustrations
23.4 x 19 x 2.4 cm, 0.96 kg
Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders.
1. Genetic Engineering in Stem Cell Manufacturing 2. Biomechanics in Stem Cell Manufacturing 3. Bioreactor Engineering Fundamentals for Stem Cell Manufacturing 4. Microcarrier Culture Systems for Stem Cell Manufacturing 5. Novel Single-Use Bioreactors for Scale up of Anchorage-Dependent Cell Manufacturing for Cell Therapies 6. Bioreactors and Downstream Processing for Stem Cell Manufacturing 7. Cell production system based on flexible modular platform 8. Microfluidic Devices for the Culture of Stem Cells 9. Enrichment and Separation Technologies for Stem Cell-Based Therapies 10. Expansion and Characterization Considerations for the Manufacturing of Stem Cells 11. Storage and Delivery of Stem Cells for Cellular Therapies 12. Business Models for Manufacture of Cellular Therapies 13. Stem cells for the regeneration of chronic wounds: a translational perspective
Subject Areas: Biochemical engineering [TC], Personal & public health [MBNH], Biotechnology industries [KNDH1]
