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Standardizing Pharmacology: Assays and Hormones
Discoveries in Pharmacology, Volume 2
Helps readers understand the science and story behind essential pharmacological discoveries from those who made them
Michael J. Parnham (Edited by), Clive Page (Edited by), Jacques Bruinvels (Edited by)
9780323855174, Elsevier Science
Hardback, published 2 March 2023
284 pages
23.5 x 19 x 2.2 cm, 0.77 kg
Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan.
Section I. Redirected traffic: the history of drugs affecting haemodynamics 1. The control of blood pressure Part 1 - The discovery of beta adrenoceptor blocking drugs Part 2 - Peripheral anti-hypertensives: ganglion and adrenergic neurone-blocking agents Section II. The discovery and application of hormones 2. The emergence of endocrinology 3. Sex hormones Part 1 - Androgens and anabolic steroids Part 2 - The biological history of the Pill Part 3 - The chemical history of the Pill Section III. Overcoming the body's defence system 4. Anti-inflammatory drugs Part 1 - The proliferation of non-steroidal anti-inflammatory drugs (NSATDS) Part 2 - The story of aspirin, H.O.J. Collier 5. The inhibition of allergic reactions Part I - Histamine receptor antagonists Part 2 - Asthma: a long and continuing story Section IV. Assays and the molecular basis of drug action 6. A probe for the fine structures of the body 7. Isolated smooth muscle in pharmacology Part 1 - The guts of the matter: contribution of studies on smooth muscle to discoveries in pharmacology Part 2 - Bioassay: a pharmacological endeavour 8. Making visible the invisible (Recollections of the first experiences with the histochemical fluorescence method for visualization of tissue monoamines) 9. Receptors in pharmacology Section V. History of chemotherapy 10. From dyes to drugs 11. The discovery of penicillin and cephalosporins 12. The antibiotic explosion
Subject Areas: Traditional medicine & herbal remedies [VXHT], Psychopharmacology [MMGW], Pharmacology [MMG], Respiratory medicine [MJL], Gastroenterology [MJH], Cardiovascular medicine [MJD], Immunology [MJCM], Oncology [MJCL], Cytology [MFCC], Clinical trials [MBGR1]
