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Single-Molecule Biophysics
Experiment and Theory, Volume 146
Tamiki Komatsuzaki (Edited by), T Komatsuzaki (Author), Masaru Kawakami (Edited by), Satoshi Takahashi (Edited by), Haw Yang (Edited by), Robert J. Silbey (Edited by), Stuart A. Rice (Series edited by), Aaron R. Dinner (Series edited by)
9781118057803, Wiley
Hardback, published 6 January 2012
512 pages
23.4 x 16 x 2.9 cm, 0.83 kg
Discover the experimental and theoretical developments in optical single-molecule spectroscopy that are changing the ways we think about molecules and atoms The Advances in Chemical Physics series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. This latest volume explores the advent of optical single-molecule spectroscopy, and how atomic force microscopy has empowered novel experiments on individual biomolecules, opening up new frontiers in molecular and cell biology and leading to new theoretical approaches and insights. Organized into two parts—one experimental, the other theoretical—this volume explores advances across the field of single-molecule biophysics, presenting new perspectives on the theoretical properties of atoms and molecules. Single-molecule experiments have provided fresh perspectives on questions such as how proteins fold to specific conformations from highly heterogeneous structures, how signal transductions take place on the molecular level, and how proteins behave in membranes and living cells.This volume is designed to further contribute to the rapid development of single-molecule biophysics research. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics.
Preface xiii Part One Developments on Single-Molecule Experiments Staring at a Protein: Ensemble and Single-Molecule Investigations on Protein-Folding Dynamics 3 Single-Molecule FRET of Protein-Folding Dynamics 23 Quantitative Analysis of Single-Molecule FRET Signals and its Application to Telomere DNA 49 Force to Unbind Ligand–Receptor Complexes and the Internal Rigidity of Globular Proteins Probed by Single-Molecule Force Spectroscopy 71 Recent Advances in Single-Molecule Biophysics with the Use of Atomic Force Microscopy 89 Dynamical Single-Molecule Observations of Membrane Protein Using High-Energy Probes 133 Single-Molecular Gating Dynamics for the KcsA Potassium Channel 147 Static and Dynamic Disorder in IN VITRO Reconstituted Receptor–Adaptor Interaction 195 Part Two Developments on Single-Molecule Theories and Analyses Change-Point Localization and Wavelet Spectral Analysis of Single-Molecule Time Series 219 Theory of Single-Molecule FRET Efficiency Histograms 245 Multidimensional Energy Landscapes in Single-Molecule Biophysics 299 Generalized Michaelis–Menten Equation for Conformation Modulated Monomeric Enzymes 329 Making it Possible: Constructing a Reliable Mechanism from a Finite Trajectory 367 Free Energy Landscapes of Proteins: Insights from Mechanical Probes 395 Mechanochemical Coupling Revealed by the Fluctuation Analysis of Different Biomolecular Motors 419 Author Index 437 Subject Index 467
By Satoshi Takahashi and Kiyoto Kamagata
By Daniel Nettels and Benjamin Schuler
By Kenji Okamoto and Masahide Terazima
By Atsushi Ikai, Rehana Afrin, and Hiroshi Sekiguchi
By Masaru Kawakami and Yukinori Taniguchi
By Yuji C. Sasaki
By Shigetoshi Oiki, Hirofumi Shimizu, Masayuki Iwamoto, and Takashi Konno
By Hiroaki Takagi, Miki Morimatsu, and Yasushi Sako
By Haw Yang
By Irina V. Gopich and Attila Szabo
By Akinori Baba and Tamiki Komatsuzaki
By Jianlan Wu and Jianshu Cao
By Ophir Flomenbom
By Zu Thur Yew, Peter D. Olmsted, and Emanuele Paci
By Hiroaki Takagi and Masatoshi Nishikawa
Subject Areas: Chemistry [PN]
