Signals, Switches, Regulons, and Cascades
Control of Bacterial Gene Expression

Discussion of current knowledge of the regulatory systems that govern bacterial gene expression.

David A. Hodgson (Edited by), C. M. Thomas (Edited by)

9780521813884, Cambridge University Press

Hardback, published 18 April 2002

304 pages, 61 b/w illus. 8 tables
23.7 x 15.8 x 2.1 cm, 0.63 kg

"...well written and illustrated..." Quarterly Review of Biology

DNA sequencing has provided a wealth of information on the genetic material stored in bacterial genomes. The use of DNA arrays and proteomics will transform the scale of our ability to describe the patterns of gene expression as bacteria respond to their environments. However, the ability to control bacteria in a clinical context or exploit them in industrial or environmental contexts also depends on understanding the regulatory mechanisms which connect input experience to output response at the genetic level. This book deals with our current knowledge of the circuits and networks that govern bacterial gene expression - from the single gene to the whole genome - and which provide the framework for explaining the data from the post genomics revolution.

Editor's preface
1. Microbial reaction to environment: bacterial stress responses revisited in the genomic-proteomic era F. C. Neidhardt
2. Gene variation and gene regulation in bacterial pathogenesis D. Hood and R. Moxon
3. DNA topology and regulation of bacterial gene expression C. J. Dorman
DNA rearrangements and regulation of gene expression I. C. Blomfield
4. Structures of multisubunit DNA-dependent RNA polymerases R. D. Finn, E. V. Orlova, M. van Heel and M. Buck
5. The ECF sigma factors of Streptomyces coelicolor A3(2) M. S. B. Paget, H-J. Hong, M. Bibb and M. J. Buttner
6. Secrets of bacterial transcription initiation taught by the Escherichia coli FNR protein D. Browning, D. Lee, J. Green and S. Busby
7. What can be learned from the LacR family of Escherichia coli? B. Muller-Hill
8. Regulation of the L-arabinose operon in Escherichia coli R. Schleif
9. Transcription termination control in bacteria T. M. Henkin
10. Antisense RNAs in programmed cell death K. Gerdes
11. Control of signal transduction in the sporulation phosphorelay J. A. Hoch
12. A stranglehold on a transcriptional activator by its partner regulatory protein - the case of the NifL-NifA two-component regulatory system R. Dixon
13. Is anybody here? Cooperative bacterial gene regulation via peptide signals between Gram-positive bacteria D. A. Morrison
14. Quorum sensing in Gram-negative bacteria: global regulons controlled by cell-density-dependent chemical signalling N. A. Whitehead, A. K. P. Harris, P. Williams and G. P. C. Salmond
Index.

Subject Areas: Microbiology [non-medical PSG], Genetics [non-medical PSAK]