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Signaling Pathways in Liver Diseases
Jean-Francois Dufour (Edited by), J Dufour (Author), Pierre-Alain Clavien (Edited by)
9781118663394, Wiley
Hardback, published 30 October 2015
520 pages
25.2 x 19.6 x 2.8 cm, 1.279 kg
Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.
List of Contributors, vii 1 Hepatocytes 1 2 Signaling pathways in biliary epithelial cells 15 3 Stellate cells 34 4 Kupffer cells 61 5 Hepatic sinusoidal endothelial cells 73 6 Extracellular matrix 85 7 Platelets: a new cell type in liver physiology 97 8 Immune cell communication in liver disease and liver regeneration 110 9 Extracellular vesicle RNA in liver disease 130 10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139 11 Autophagy 151 12 CXC chemokine receptor signaling in liver repair and regeneration 166 13 Metabolic regulation of liver regeneration 174 14 TNF signaling 186 15 Fas/FasL 203 16 Interferon signaling 214 17 Endocannabinoid signaling in liver pathologies 226 18 The WNT/β]catenin pathway 240 19 Hedgehog signaling in the liver 262 20 Notch pathway 275 21 PI3K/PTEN signaling in liver diseases 287 22 mTOR signaling in liver disease 314 23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326 24 NF-κB 339 25 c-Jun NH2]terminal kinases in liver diseases 348 26 p53 364 27 Sirtuins 374 28 Bile acids and their receptors 385 29 Hepcidin and iron 400 30 Gut microbiome and liver diseases 411 31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421 32 Signaling in hepatocellular carcinoma 435 33 Interplay between hepatitis B virus and innate immune signaling pathways 448 34 Signaling of hepatitis C virus 459 35 Oxidative stress and signaling in the liver 469 Index 000
Jean-François Dufour and Joachim C. Mertens
M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson
Alessandra Caligiuri and Fabio Marra
Amirali Kiyani and Ekihiro Seki
Moira B. Hilscher Robert C. Huebert and Vijay H. Shah
Scott L. Friedman
Mickaël Lesurtel and Pierre]Alain Clavien
R. Harminder Boghal, B.F. Stephenson and Simon C. Afford
Tushar Patel and Hiroaki Haga
Fabienne Foufelle and Pascal Ferré
Hao Zhang, Bilon Khambu and Xiao]Ming Yin
Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch
Jiansheng Huang and David A. Rudnick
Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg
Maria Eugenia Guicciardi and Gregory J. Gores
Markus H. Heim
Bostjan Humar and Nasser Semmo
Satdarshan P. Singh Monga
Mariana V. Machado and Anna Mae Diehl
Sonja Rothweiler and David Semela
Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti
Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall
Benoit Viollet and Marc Fortes
Ekihiro Seki and David A. Brenner
Johannes Kluwe and Robert F. Schwabe
Aundrietta D. Duncan, Wen]Wei Tsai and Michelle Craig Barton
Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey
Thierry Claudel and Michael Trauner
Chiara Vecchi and Antonello Pietrangelo
Herbert Tilg and Alexander R. Moschen
Jelena Mann and Derek A. Mann
Adam Pennycuick and Augusto Villanueva
Barbara Testoni, David Durantel and Fabien Zoulim
Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert
Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke
Subject Areas: Medicine: general issues [MB]
