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Signal Transduction
This comprehensive, up-to-date book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated, providing users with an invaluable resource for advanced undergraduates, graduate students, and established scientists.
ljsbrand M. Kramer (Author)
9780123948038, Elsevier Science
Hardback, published 31 December 2015
1104 pages
22.9 x 15.1 x 5.1 cm, 1.95 kg
A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition.
1. Prologue: Signal Transduction from a Historical Perspective2. An Introduction to Signal Transduction3. Regulation of Muscle Contraction by Receptors4. Cholinergic Signaling and Muscle Contraction5. Sensory Signal Processing; Visual Transduction and Olfaction6. Intracellular Calcium7. Bringing the Signal into the Nucleus: Regulation of Gene Expression8. Nuclear Receptors9. Protein Kinase C and Oncogenic Transformation and Cell Polarity10. Regulation of Cell Proliferation by Receptor Tyrosine Protein Kinases11. Signal Transduction to and from Adhesion Molecules12. WNT Signaling and the Regulation of Cell Adhesion and Differentiation13. Activation of the Innate Immune System: the Toll-Like Receptor-4 and Signaling through Ubiquitylation14. Chemokines and Traffic of White Blood Cells15. Activating the Adaptive Immune System: Role of Non-receptor Tyrosine Kinases16. Signaling through the Insulin Receptor: Phosphoinositide 3-Kinases and AKT17. TGFß and Signaling through Receptor Serine/Threonine Protein Kinases18. Protein Phosphates19. Cell Fate Determination by Notch
