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Side Reactions in Peptide Synthesis

A systematic analysis of the most frequently occurring side reactions in peptide synthesis, ideal for research and process chemists working in diverse settings across academic, biotech, and pharmaceutical research and development

Yi Yang (Author)

9780128010099, Elsevier Science

Hardback, published 8 September 2015

376 pages, Illustrations: 100-150
22.9 x 15.1 x 2.6 cm, 0.73 kg

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.

While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.

Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

  1. Peptide Fragmentation/Deletion
  2. Premature FMOC Deprotection
  3. Elimination Side Reactions
  4. Peptide Global Deprotection/Scavenger-Induced Side Reactions
  5. Peptide Rearrangement Side Reactions
  6. Side Reactions Occurring at Amino Acid/Peptide Activation Step
  7. Intramolecular Cyclization Side Reactions
  8. Side Reactions in Amino Groups in Peptide Synthesis
  9. Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
  10. Oxidation and Reduction Side Reactions in Peptide Synthesis
  11. Racemization in Peptide Synthesis
  12. Solvent and Residual Impurities in the Reagents Induced Side Reactions
  13. Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
  14. Reattachment of Peptides to the Solid Supports
  15. Addition Side Reactions in Peptide Synthesis
  16. Side Reactions in Phosphor Peptides
  17. Side Reactions in CYS
  18. Protein Fragmentations

Subject Areas: Biochemistry [PSB], Organic chemistry [PNN]

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