Scientific Principles of Adipose Stem Cells

A resource for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles

Lauren Kokai (Edited by), Kacey Marra (Edited by), J. Peter Rubin (Edited by)

9780128193761, Elsevier Science

Paperback, published 25 August 2021

484 pages, 90 illustrations (60 in full color)
27.6 x 21.6 x 3 cm, 0.45 kg

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine.  Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included.

Part 1 Introduction and front matter
1. Plastic surgery, fat, and fat plasticity: How adipose tissue changed the landscape of stem cell therapeutics
Lauren Kokai and J. Peter Rubin
Part 2 Basic biology of adipose stem cells
2. Developmental origins of adipocytes: What we learn from human pluripotent stem cells
Xi Yao, Vincent Dani, and Christian Dani
3. Establishing the adipose stem cell identity: Characterization assays and functional properties
Mark A.A. Harrison, Sara I. Al-Ghadban, Benjamen T. O’Donnell, Omair A. Mohiuddin, Rachel M. Wise, Brianne N. Sullivan, and Bruce A. Bunnell
4. Insights into the adipose stem cell niche in health and disease
Aaron C. Brown
5. Mechanisms of adipose-derived stem cell aging and the impact on therapeutic potential
Xiaoyin Shan and Ivona Percec
6. Human pluripotent nontumorigenic multilineage differentiating stress enduring (Muse) cells isolated from adipose tissue: A new paradigm in regenerative medicine and cell therapy
Karen L. Leung and Gregorio D. Chazenbalk
7. Adipose stem cell homing and routes of delivery
Ganesh Swaminathan, Yang Qiao, Bhavesh D. Kevadiya, Lucille A. Bresette, Daniel D. Liu, and Avnesh S. Thakor
8. Bioreactors and microphysiological systems for adipose-based pharmacologic screening
Mallory D. Griffin and Rosalyn D. Abbott
Part 3  Adipose cell therapy and regenerative medicine
9. Adipose stem cells and donor demographics: Impact of anatomic location, donor sex, race, BMI, and health
Adam Cottrill, Yasamin Samadi, and Kacey G. Marra
10. Immunomodulatory properties of adipose stem cells in vivo: Preclinical and clinical applications
Matthias Waldner, Fuat Baris Bengur, and Lauren Kokai
11. Clinical experience with adipose tissue enriched with adipose stem cells
Shawn Loder, Danielle Minteer, and J. Peter Rubin
12. Adipose-derived stem cells for wound healing and fibrosis
Y Samadi, FM Egro, RL Rodriguez, and A Ejaz
13. Oncologic safety of adipose-derived stem cell application
Hakan Orbay and David E. Sahar
14. FDA regulation of adipose cell use in clinical trials and clinical translation
Mary Ann Chirba, Veronica Morgan Jones, Patsy Simon, and Adam J. Katz
Part 4 Engineering with adipose stem cell
15. Biomaterial control of adipose-derived stem/stromal cell differentiation
John Walker and Lauren Flynn
16. Genetic modification of adipose-derived stem cells for bone regeneration
Harsh N. Shah, Abra H. Shen, Sandeep Adem, Ankit Salhotra, Michael T. Longaker, and Derrick C. Wan
17. Adipose-derived stromal/stem cells for bone tissue engineering applications
Nathalie Faucheux, Fabien Kawecki, Jessica Jann, Franc¸ois A. Auger, Roberto D. Fanganiello, and Julie Fradette
18. The hematopoietic potential of stem cells from the adipose tissue
Beatrice Cousin and Louis Casteilla
19. Adipose stem cells for peripheral nerve engineering
Benjamin K. Schilling, George E. Panagis, Jocelyn S. Baker, and Kacey G. Marra

Subject Areas: DNA & Genome [PSAK1], Life sciences: general issues [PSA]