Sarcopenia
Molecular Mechanism and Treatment Strategies

Defines and explains the clinical relevance of sarcopenia, discussing treatment options and covering up-to-date research

Kunihiro Sakuma (Edited by)

9780128221464, Elsevier Science

Paperback, published 23 July 2021

342 pages, 100 illustrations (75 in full color)
23.4 x 19 x 2.2 cm, 0.7 kg

Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.

1. The definition of sarcopenia and the physical measures being associated with sarcopenia 2. Mitochondrial dysfunction linking to sarcopenia 3. The regulation of MicroRNA for sarcopenia 4. The relationship between neuromuscular junction and sarcopenia 5. The functional role of satellite cells in sarcopenic muscle 6. The molecular mechanisms of age-related anabolic resistance 7. The autophagic defect in sarcopenic muscle 8. Mitophagy system in sarcopenic muscle 9. Sarcopenia and the inflammatory cytokines 10. Skeletal muscle ECM remodeling and sarcopenia 11. Underlying mechanisms of sarcopenic obesity 12. Dysphagia in sarcopenia and cachexia 13. Under adjustment 14. Molecular mechanism of exercise for combating sarcopenia 15. Dietary approaches to maintain muscle mass 16. Pharmacological strategy for sarcopenia 17. Stem cells and sarcopenia with some translational aspect 18. Metabolic reprogramming attenuating sarcopenia

Subject Areas: Diabetes [MJGD]