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Regulating with RNA in Bacteria and Archaea
Gisela Storz (Edited by), G Storz (Author), Kai Papenfort (Edited by)
9781683670230, Wiley
Hardback, published 1 November 2018
575 pages
28.2 x 21.8 x 3.6 cm, 1.973 kg
Finally! One spectacular volume provides us all we need to educate ourselves in the fascinating world of regulatory RNAs in bacteria and archaea. From the genetics to the biochemistry to the mechanisms to the structures to the physiology to the networks to the challenges for the future—it's all here—laid out for us in exceptional form by the world's key experts. This volume is an eye-opening must read about one of microbiology's most exciting emerging fields.
-Bonnie L. Bassler, Ph.D., HHMI Investigator, Squibb Professor and Chair of the Department of Molecular Biology, Princeton University
Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.
Contributors Foreword Preface Acknowledgments About the Editors Section I: RNases and Helicases 1. RNase E and the High-Fidelity Orchestration of RNA Metabolism 2. Enzymes Involved in Posttranscriptional RNA Metabolism in Gram-Negative Bacteria 3. RNases and Helicases in Gram-Positive Bacteria Section II: Cis-acting RNAs 4. RNA Thermometers in Bacterial Pathogens 5. Small Molecule-Binding Riboswitches 6. The T-Box Riboswitch: tRNA as an Effector to Modulate Gene Regulation 7. rRNA Mimicry in RNA Regulation of Gene Expression 8. Processive Antitermination 9. Genes within genes in bacterial genomes 10. Leaderless mRNAs in the Spotlight: Ancient but Not Outdated! Section III: Cis-encoded base pairing RNAs 11. Type I Toxin-Antitoxin Systems: Regulating Toxin Expression via Shine-Dalgarno Sequence Sequestration and Small RNA Binding 12. Widespread Antisense Transcription in Prokaryotes Section IV: Trans-encoded base pairing RNAs 13. Small Regulatory RNAs in the Enterobacterial Response to Envelope Damage and Oxidative Stress 14. Carbohydrate Utilization in Bacteria: Making the Most Out of Sugars with the Help of Small Regulatory RNAs 15. Small RNAs Involved in Regulation of Nitrogen Metabolism 16. Bacterial Iron Homeostasis Regulation by sRNAs 17. Small-RNA-Based Regulation of Bacterial Quorum Sensing and Biofilm Formation 18. Regulatory RNAs in Virulence and Host-Microbe Interactions Section V: Protein titration and scaffolding 19. Global Regulation by CsrA and Its sRNA Antagonists 20. 6S RNA, a Global Regulator of Transcription 21. Bacterial Y RNAs: Gates, Tethers, and tRNA Mimics Section VI: General considerations 22. Proteins That Chaperone RNA Regulation 23. Epitranscriptomics: RNA Modifications in Bacteria and Archaea 24. RNA Localization in Bacteria 25. Sponges and Predators in the Small RNA World 26. Bacterial Small RNAs in Mixed Regulatory Networks 27. Dual-Function RNAs 28. Origin, Evolution, and Loss of Bacterial Small RNAs Section VII: Emerging topics 29. Cross-regulation between bacteria and phages at a posttranscriptional Level 30. Large Noncoding RNAs in Bacteria 31. Synthetic Biology of Small RNAs and Riboswitches Section VIII: Resources 32. Functional Transcriptomics for Bacterial Gene Detectives 33. Structure and Interaction Prediction in Prokaryotic RNA Biology Index
Katarzyna J. Bandyra and Ben F. Luisi
Bijoy K. Mohanty and Sidney R. Kushner
Sylvain Durand and Ciarán Condon
Edmund Loh, Francesco Righetti, Hannes Eichner, Christian Twittenhoff, Franz Narberhaus
Thea S. Lotz and Beatrix Suess
Kiel D. Kreuzer and Tina M. Henkin
Michelle M. Meyer
Jonathan R. Goodson and Wade C. Winkler
Sezen Meydan, Nora Vázquez-Laslop, and Alexander S. Mankin
Heather J. Beck and Isabella Moll
Sara Masachis and Fabien Darfeuille
Jens Georg and Wolfgang R. Hess
Kathrin S. Fröhlich and Susan Gottesman
Svetlana Durica-Mitic, Yvonne Göpel, Boris Görke
Daniela Prasse and Ruth A. Schmitz
Sylvia Chareyre and Pierre Mandin
Sine Lo Svenningsen
Alexander J. Westermann
Tony Romeo and Paul Babitzke
Karen M. Wassarman
Soyeong Sim and Sandra L. Wolin
Sarah A. Woodson, Subrata Panja, and Andrew Santiago-Frangos
Katharina Höfer and Andres Jäschke
Jingyi Fei and Cynthia M. Sharma
Nara Figueroa‐Bossi and Lionello Bossi
Anaïs Brosse and Maude Guillier
Medha Raina, Alisa King, Colleen Bianco, and Carin K. Vanderpool
H. Auguste Dutcher and Rahul Raghavan
Shoshy Altuvia, Gisela Storz, Kai Papenfort
Kimberly A. Harris and Ronald R. Breaker
Jordan K. Villa, Yichi Su, Lydia M. Contreras, Ming C. Hammond
Blanca Perez-Sepulveda and Jay C.D. Hinton
Patrick R. Wright, Martin Mann, Rolf Backofen
Subject Areas: Clinical & internal medicine [MJ]
