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Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders
A concise reference on receptor tyrosine kinases in neurodegenerative disease and in the healthy central nervous system
Heba Mohamed Mansour (Edited by), Mahmoud Mohamed Khattab (Edited by), Aiman Saad El-Khatib (Edited by)
9780443186776, Elsevier Science
Paperback / softback, published 8 June 2023
604 pages
22.9 x 15.2 x 3.7 cm, 1.25 kg
Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.
1. The Molecular Pathology of Neurodegenerative And Psychiatric Disorders 2. Receptor Tyrosine Kinases: An Overview 3. Roles of TRK Receptors, Tyrosine Kinase Receptors for Neurotrophins, in the Developing CNS 4. Receptor Tyrosine Kinase (RTKs): from biology to pathophysiology 5. Growth Factors and Their Receptors: Multitasking Functionality in Health and Disease 6. Regulation of Receptor Tyrosine Kinase Gene Expression 7. Role Of Receptor Tyrosine Kinases in Neurodegenerative Disorders 8. Insights into Receptor Tyrosine Kinase Signaling in Neurodegenerative Disorders: Opportunities and Translational Perspectives 9. Receptor Tyrosine Kinases in Major Depressive Disorder 10. Repositioning of Receptor Tyrosine Kinase Inhibitors: From Cancer to Neurodegenerative And Psychiatric Disorders 11. Protein Kinase Inhibitors as Therapeutics in Neurodegenerative and Psychiatric Disorders: Progress, Challenges, and Recommendations
Subject Areas: Neurosciences [PSAN], Science: general issues [PD]
