Recent Trends in Carbohydrate Chemistry
Synthesis and Biomedical Applications of Glycans and Glycoconjugates

Presents the most recent synthetic methodologies in carbohydrate chemistry from an international team of experts

Amélia Pilar Rauter (Edited by), Bjørn E. Christensen (Edited by), László Somsák (Edited by), Paul Kosma (Edited by), Roberto Adamo (Edited by)

9780128209547, Elsevier Science

Paperback, published 29 April 2020

438 pages
22.9 x 15.1 x 2.8 cm, 0.68 kg

Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development.

I. Advances in chemical synthesis and biosynthesis of bacterial glycans 1. Prokaryotes: Sweet proteins do matter 2. Glycan ligation reactions in the periplasmic space 3. Synthesis of bioactive lipid A and analogues 4. Synthesis of lipopolysaccharide core fragments 5. Synthesis of oligosaccharides related to potential bioterrorist pathogens 6. Synthetic teichoic acid chemistry for vaccine applications 7. NMR characterization of bacterial glycans and glycoconjugate vaccines

Subject Areas: Organic chemistry [PNN]