Recent Advances in iPSC Technology

Discusses the possible origins and consequences of stem cells and their differences between distinct organs

Alexander Birbrair (Edited by)

9780128222317

Paperback, published 7 April 2021

334 pages, 60 illustrations (40 in full color)
23.4 x 19 x 2.2 cm, 0.7 kg

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies.Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more.The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

1. Modeling the Cardiovascular Toxicities of Anticancer Therapies in the Era of Precision Medicine
2. Looking at Induced Pluripotent Stem Cell (iPSCs) Differentiation Through the Lens of The Non-Coding Genome
3. In Vitro Blood-Brain Barrier Model Derived from Human Ips Cells and Its Applications
4. The Progress in The Study of Reprogramming to Acquire the Features of Stem Cells In iPSCs and Cancers
5. An Introduction to The Mathematical Modelling of iPSCs
6. Use of iPSCs-Derived Brain Organoids to Study Human Brain Evolution
7. Self-Renewal in Induced Pluripotent Stem Cells
8. Strategies for iPSCs Expansion
9. An Overview of Reprogramming Approaches to Derive Integration-Free Induced Pluripotent Stem Cells for Prospective Biomedical Applications
10. Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: A Comprehensive Overview of Differences and Similarities

Subject Areas: Life sciences: general issues [PSA]