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Quinones and Quinone Enzymes, Part B
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups.
Helmut Sies (Volume editor), Lester Packer (Volume editor)
9780121827861, Elsevier Science
Hardback, published 8 March 2004
572 pages, Approx. 150 illustrations
22.9 x 15.1 x 3.2 cm, 0.96 kg
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.
Section I: Mitochondrial Ubiquinone and Reductases 1: Mitochondrial Quinone Reductases: Complex I 2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes 3: Targeting Coenzyme Q Derivatives to Mitochondria 4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia 5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency 6: Coenzyme Q Cytoprotective Mechanisms 7: Dietary Coenzyme Q10 and Mitochondrial Status Section II: Anticancer Quinones and Quinone Oxidoreductases 8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics 9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO) 10: Diaziridinylbenzoquinones 11: Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications 12: Bioactivation and Resistance to Mitomycin C 13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells 14: The “Prochaska? Microtiter Plate Bioassay for Inducers of NQO1 15: Structure-Activity Relationships in Two-Electron Reduction of Quinones 16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1 17: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases 18: Induction of NQO1 in Cancer Cells Section III: Quinone Reductases: Chemoprevention and Nutrition 19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates 20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase 21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens 22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes 23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1) 24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview 25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli Section IV: Quinones and Age-Related Diseases 26: Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases 27: Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease Author Index Subject Index
Subject Areas: Enzymology [PSBZ], Biochemistry [PSB], Biophysics [PHVN], Endocrinology [MJG]
