• Quadruplex Nucleic Acids As Targets For Medicinal Chemistry (Hardback) 9780128210178
1 1
£92.19 GBP
£137.00 GBP £92.19 GBP
Sale Sold out
Free UK Shipping

Freshly Printed - allow 10 days lead

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Contains contributions from the best scientists in medicinal chemistry who present the latest developments in the field

Stephen Neidle (Series edited by)

9780128210178, Elsevier Science

Hardback, published 25 August 2020

564 pages
22.9 x 15.1 x 3.2 cm, 1.04 kg

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

Part 1. Fundamentals of quadruplexes and their biology

    1. Fundamentals of G-quadruplex biology

      2. F. Brad Johnson

    2. Quadruplex structure and diversity

      3. Fernaldo Richtia Winnerdy and Anh Tuân Phan

      Part 2. Quadruplex targets in human and other organisms

    3. Telomeric quadruplexes as therapeutic targets

      4. Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama

    4. Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

      5. Emanuela Ruggiero and Sara N. Richter

    5. Quadruplex detection in human cells

      6. David Monchaud

      Part 3. Discovery and design of quadruplex-binding compounds

    6. An overview of quadruplex ligands: Their common features and chemotype diversity

      7. Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria

    7. Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding

      8. Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider

    8. Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers

      9. Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou

    9. Click and combinatorial approaches to quadruplex ligand discovery

      10. Jyotirmayee Dash, Puja Saha and Khushnood Fatma

    10. Quadruplex nucleic acids in KRAS targeted-cancer therapy

      11. Luigi E. Xodo

    11. Transcriptional regulation of MYC through G-quadruplex structures

      12. Sumirtha Balaratnam and John S. Schneekloth

    12. KIT promoter: Structure, function and targeting

      13. Silvia Ceschi and Claudia Sissi

    13. Quadruplex targets in neurodegenerative diseases

      14. Janez Plavec

    14. Metal complexes as G-quadruplex binders

      15. Tim Kench and Ramon Vilar

    15. Challenges in developing small-molecule quadruplex therapeutics

Stephen Neidle

Subject Areas: Chemistry [PN], Pharmacology [MMG]
View full details