• Protein Structure and Diseases (Hardback) 9780123812629
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Protein Structure and Diseases

This volume presents step-by-step techniques for researchers that will predict the structure and potential function of proteins by identifying its coding sequence

Rossen Donev (Volume editor)

9780123812629, Elsevier Science

Hardback, published 12 July 2011

312 pages
22.9 x 15.1 x 2.3 cm, 0.66 kg

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

  1. Graphical representation and mathematical characterization of protein sequences and applications to viral proteinsAmbarnil Ghosh and Ashesh Nandy

  2. Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyriaArola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet

  3. Role of Fibrin Structure in Thrombosis and Vascular DiseaseAmy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns

  4. Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational ViewAnton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov

  5. Proteins MOVE! Protein dynamics and long-range allostery in cell signalingZimei Bu and David J. E. Callaway

  6. Structural diversity of class I MHC like molecules and its implications in binding specificitiesMd. Imtaiyaz Hassan and Faizan Ahmad

Subject Areas: Molecular biology [PSD], Proteins [PSBC], DNA & Genome [PSAK1], Pharmacology [MMG]
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