Protein-Protein Interactions in Human Disease, Part A

Overview of advances in the role of protein-protein interactions in human diseases, with promising new strategies based on targeting protein interactions

Rossen Donev (Volume editor)

9780128143445, Elsevier Science

Hardback, published 24 January 2018

288 pages
22.9 x 15.1 x 2.3 cm, 0.61 kg

"...all of the authors of the book succeeded in showing highly exciting and unique opportunities for unraveling the functional behavior of complex protein-protein interactions in human diseases. ...The volume shows the enormous complexity in the field of PPI in human diseases. It is a collection of topics without pretending in-depth analysis of a single subject. Each theme and chapter stands on its own, but all have protein-protein interactions in common." --The Quarterly Review of Biology

Protein-Protein Interactions in Human Disease, Part A, Volume 110 aims to promote further research and development in the protein interaction network as a means to not only identify the critical proteins involved in the etiology of human diseases, but also identify new protein targets for drug development. Sections cover such topics as protein-protein interaction modulators for epigenetic therapies, intrinsic disorder, protein-protein interactions and disease, targeting protein-protein interactions in the ubiquitin-proteasome pathway, the proteomics of occupational diseases, and computational methods in predicting the impact of SNPs in protein-protein network, amongst other topics.

1. Analysis of protein interactions by surface plasmon resonance Dennis G. Drescher 2. Using TR-FRET to investigate protein-protein interactions: a case study of PXR-coregulator interaction Taosheng Chen 3. Protein-Protein Interaction Modulators for Epigenetic Therapies Jose L. Medina-Franco 4. Intrinsic disorder, protein-protein interactions and disease Vladimir N. Uversky 5. Targeting protein-protein interactions in the ubiquitin-proteasome pathway Maria Gaczynska 6. Protein-protein networks involved in MODY family George Priya Doss P. C 7. Defining HIV-1 replication mechanisms by analyzing virus-host protein interactions Manuel Llano 8. Proteomics of occupational diseases Nicola Luigi Bragazzi 9. Proteomics of sport-related injuries Nicola Luigi Bragazzi 10. Structural prediction of protein-protein interactions by docking: application to biomedical problems Juan Fernandez-Recio 11. Computational methods in predicting the impact of SNPs in Protein-protein network George Priya Doss P. C

Subject Areas: Biochemistry [PSB]