Protein Kinases in Drug Discovery

A great resource for studying the structure and function of transport proteins and their implication in drug design and drug delivery

Rossen Donev (Edited by)

9780323853132, Elsevier Science

Hardback, published 25 February 2021

350 pages
22.9 x 15.2 x 2.5 cm, 0.79 kg

Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.

1. Transporter proteins and its implication in human diseases Ritika Kabra and Shailza Singh 2. Protein kinase CK2 inhibition as a pharmacological strategy Christian Borgo and Maria Ruzzene 3. Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy Preeti Gupta, Aaliya Taiyab, and Md Imtaiyaz Hassan 4. Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation Mingyu Li, Ashfaq Ur Rehman, Yaqin Liu, Kai Chen, and Shaoyong Lu 5. Pseudokinases: Prospects for expanding the therapeutic targets armamentarium Nayana Devang, Adyashree Pani, and G.K. Rajanikant 6. Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseases Joyce Villa Verde Bastos Borba, Arthur Carvalho Silva, Marilia Nunes Nascimento Lima, Sabrina Silva Mendonca, Nicholas Furnham, Fabio Trindade Maranhão Costa, and Carolina Horta Andrade 7. Targeting malaria protein kinases G.C. Cassiano, T.A. Tavella, M.N. Nascimento, D.A. Rodrigues, P.V.L. Cravo, Carolina Horta Andrade, and Fabio Trindade Maranhão Costa 8. Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases T.A. Tavella, G.C. Cassiano, Fabio Trindade Maranhão Costa, P. Sunnerhagen, and E. Bilsland 9. Structural studies of full-length receptor tyrosine kinases and their implications for drug design Adam Bajinting and Ho Leung Ng

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Biochemistry [PSB]