Proteases in Health and Disease

Reviews the latest developments in this field

Enrico Di Cera (Edited by)

9780123855046, Elsevier Science

Hardback, published 7 March 2011

328 pages
22.9 x 15.1 x 2.4 cm, 0.58 kg

PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments.

1. Membrane-Anchored Serine Proteases in Health and Disease Toni M. Antalis, Thomas Bugge, and Qingyu Wu 2. Complex Assemblies of Factor IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood Coagulation Thomas Zögg and Hans Brandstetter 3. Structure and Proteolytic Properties of ADAMTS13, a Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies Stefano Lancellotti and Raimondo De Cristofaro 4. Thrombin as an Anticoagulant Enrico Di Cera 5. Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily Steven T. Olson and Peter G.W. Gettins 6. Multiple Roles of Metalloproteinases in Neurological Disorders Yi Yang, Jeff W. Hill, and Gary A. Rosenberg

Subject Areas: Enzymology [PSBZ]