Progress in Medicinal Chemistry

F.D. King (Author)

9780444511430, Elsevier Science

Hardback, published 15 April 2004

0 pages
22.9 x 15.1 x 1.3 cm, 0.69 kg

This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.

Subject Areas: Pharmaceutical technology [TDCW], Chemistry [PN], Medicine: general issues [MB]