Progress in Medicinal Chemistry

Contains eclectic developments in medicinal chemistry, with authoritative reviews of targets and technologies that address new therapeutics

David R. Witty (Series edited by), Brian Cox (Series edited by)

9780128152133, Elsevier Science

Hardback, published 10 April 2018

366 pages
22.9 x 15.1 x 2.5 cm, 0.71 kg

Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

1. Discovery and Development of Calcimimetic and Calcilytic Compounds Edward F. Nemeth, Bradford C. Van Wagenen and Manuel F. Balandrin 2. VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine) Nicole D. Harriott, John P. Williams, Evan B. Smith, Haig P. Bozigian and Dimitri E. Grigoriadis 3. Current Trends in Macrocyclic Drug Discovery and Beyond-Ro5 Sulejman Alihodzic, Mirjana Bukvic, Ivaylo J. Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pesic, Gordon Saxty, Linda Tomaškovic and Dinko Ziher 4. Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR Phil R. Kym, Xueqing Wang, Mathieu Pizzonero and Steven E. Van der Plas 5. Big Data in Drug Discovery Nathan Brown, Jean Cambruzzi, Peter J. Cox, Mark Davies, James Dunbar, Dean Plumbley, Matthew A. Sellwood, Aaron Sim, Bryn I. Williams-Jones, Magdalena Zwierzyna and David W. Sheppard

Subject Areas: Organic chemistry [PNN], Pharmacology [MMG]