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Practical Transfusion Medicine

Michael F. Murphy (Author), Nancy M. Dunbar (Author), Erica M. Wood (Author)

9781394291960, Wiley

Hardback, published 21 May 2026

448 pages
25.6 x 18.5 x 2.8 cm, 1.043 kg

Provides practical, evidence-based guidance for managing transfusion practice and patient care in patients who may require transfusion.

The rapid evolution of transfusion medicine, shaped by advances in science, technology, and global practice, demands an authoritative and up-to-date resource. Practical Transfusion Medicine, Seventh Edition, meets this need by offering a comprehensive and clinically grounded guide to the principles and practice of transfusion medicine. Building on the trusted foundations of previous editions, it balances depth of coverage with accessibility, making it an indispensable resource for trainee and practising haematologists, clinical and scientific staff working in transfusion services, and clinicians treating patients who may require transfusion.

This new edition reflects the considerable changes in the field since 2022, incorporating new sections on patient blood management, cellular and tissue therapy, and organ transplantation. A dedicated chapter on cardiorespiratory complications including transfusion-associated circulatory overload highlights their importance as a complication of transfusion, whilst the restructured clinical practice section offers a more focused approach to transfusion management across medical, surgical, and haematology patients. With contributions from leading international experts, the text provides evidence-based insights supported by numerous charts, tables, and algorithms.

Practical Transfusion Medicine, Seventh Edition:

  • Integrates scientific, clinical, and regulatory perspectives with global context
  • Provides detailed coverage of transfusion-associated complications and their management
  • Features expanded sections on patient blood management, tissue therapy, and transplantation
  • Balances comprehensive detail with clarity, offering more depth than handbooks yet more accessibility than reference tomes
  • Addresses both acute clinical decision-making and long-term patient management

Practical Transfusion Medicine, Seventh Edition, is essential for postgraduate and specialist trainees in haematology preparing for examinations such as the FRCPath in the UK, as well as for trainees in the many specialties where transfusions are used. It is equally valuable as a reference tool for established clinicians treating patients requiring transfusion and for clinical and scientific staff working in transfusion services.

List of Contributors viii

Preface to the Seventh Edition xv

Part I Introduction 1

1 Past, Present and Future of Transfusion Medicine 1
Richard M. Kaufman

Part II Basic Principles of Immunohaematology and Transplantation 10

2 Essential Immunology for Transfusion Medicine 10
Connie M. Arthur and Sean R. Stowell

3 Red Blood Cell Antigens and Antibodies 19
Jennifer R. Hagman and Jill R. Storry

4 Platelet, Neutrophil and Leucocyte Antigens and Antibodies 31
Louise Helander and Caroline R. Alquist

Part III Overarching Principles of Good Practice in Transfusion Medicine 46

5 Evidence-Based Transfusion Medicine 46
Adam Irving, Khai L. Chai, Susan J. Brunskill, and Zoe K. McQuilten

6 Quality Management in Transfusion Medicine 59
Sarah L. Morley, Gustavo C. Duarte, and Fidelma Murphy

7 Donors and Blood Collection 70
Marc Germain and Pierre Tiberghien Copyrighted Material

8 Principles of Patient Blood Management 82
Allison Mo and Monica B. Pagano

9 The Role of Haemovigilance in Transfusion Safety 104
Barbee I. Whitaker, Katharine A. Downes, and Johanna C. Wiersum-Osselton

10 Emergency Blood Preparedness 115
Torunn O. Apelseth and Tom Scorer

Part IV Practice in Blood Centres and Hospitals 122

11 Blood Donation Testing and the Safety of the Blood Supply 122
Agbonbhaselena Omonua, Susan R. Brailsford, and Stephen Thomas

12 Production and Storage of Blood Components 132
Denese Marks and Susanne Marschner

13 Pre-transfusion Testing and the Selection of Products for Transfusion 148
Chris Hogan and Alison Davies

14 Hospital Oversight of Transfusion Safety and the Appropriate Use of Blood 159
Nicole Relke, Susan Nahirniak, and Andrew W. Shih

Part V Clinical Transfusion Practice 178

15 Inherited and Acquired Red Cell Disorders 178
Raisa Balbuena-Merle, Christopher A. Tormey, and David Raggay

16 Inherited and Acquired Platelet Disorders 190
Anand Padmanabhan and Dong Chen

17 Inherited and Acquired Disorders of Coagulation 204
Emmanuel J. Favaloro, Marian Rollins-Raval, and Rajiv Pruthi

18 Transfusion in Patients with Major Haemorrhage 222
Aaron Stansbury Hess

19 Elective Transfusions 233
Simon J. Stanworth and Akshay Shah

20 Obstetric Transfusion Medicine 243
Anna Parakh, Erin O’Reilly, and Helen Savoia

21 Neonatal, Infant and Paediatric Transfusion 255
Anne M. Kelly

22 Plasma Derivatives 267
Matea Vinković Vlah, Anja Mäkelburg, and Cynthia So-Osman

23 Therapeutic Apheresis 279
Andrew D. Johnson and Nicole D. Zantek
Contents vii

Part VI Complications of Transfusion 292

24 Approach to the Investigation and Management of a Patient with a Suspected Transfusion Reaction 292
HyoJeong Han and Meghan Delaney

25 Acute Haemolytic Transfusion Reactions 306
Courtney K. Hopkins and Rim Abdallah

26 Allergic and Anaphylactic Transfusion Reactions 318
Liz Marinaro and Ralph Vassallo

27 Respiratory Complications of Transfusion 326
Tom Latham, Rick Kapur, Alexander Vlaar, and Paula HB Bolton-Maggs

28 Complications of Transfusion: Bacterial Sepsis 339
Michel-Andrés García-Otálora, Sylvia Ighem-Chi, and Sandra Ramírez-Arcos

29 Delayed Complications of Blood Transfusion 351
France Pirenne and Mariane de Montalembert

30 Transfusion-Transmitted Infections – Pathogens of Concern 364
Brian Custer

31 Transfusion-Transmitted Infections – Interventions and Measuring Risk 373
Brian Custer

Part VII Cellular Therapy and Transplantation 382

32 Haematopoietic Cell Transplantation 382
Laura Connelly-Smith

33 Cellular Immunotherapy 397
Daniel North, Louis Peters, and Ronjon Chakraverty

34 Tissue Banking 409
Clint S. Schmidt, Kristen L. Rodriguez, Michael C. Deeds, and Eapen K. Jacob

Index 417

Subject Areas: Clinical & internal medicine [MJ]
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