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Practical Biostatistics
A Friendly Step-by-Step Approach for Evidence-based Medicine
A concise guide for the interpretation and writing of observational studies and clinical trials
Mendel Suchmacher (Author), Mauro Geller (Author)
9780124157941, Elsevier Science
Paperback, published 14 September 2012
248 pages, 65 illustrations (15 in full color)
22.9 x 15.1 x 1.7 cm, 0.34 kg
"...strongly recommended as a practical guide for readers interested in applied biostatistics. Each chapter of the book is accompanied by practical examples and a huge set of reflection questions and answers." --Zentralblatt MATH, Practical Biostatistics "With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials." --Doody.com, April 2013 "Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." --Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida "This work by Dr. Suchmacher and Dr. Geller is bound to become a classic and should be readily available on the desk, shelf and on line." --Salin Dahlben, Harvard University, Clinical Assistant Professor in Psychiatry, Tufts University "Dr. Suchmacher and Dr. Geller are experienced researchers and writers in the clinical research field, who were able to fathom the often confusing realm of Statistics applied to biological sciences, and to come back with a pragmatic study proposal for interested medical students and healthcare professionals […] In my opinion, 'Practical Biostatistics' will undoubtedly be welcomed as one of the books designed to bring medical students and healthcare professionals alike, closer to a better understanding of this inescapable issue." --Spyros G.E. Mezitis, Assistant Professor of Clinical Medicine, The New York Presbyterian Hospital Weill, Cornell Medical Center "I believe the result of [Drs. Suchmacher and Geller’s] efforts will prove useful for many medical students and researchers, who must thrive in an era when Biostatistics is destined to be an ever present matter." --Allan E. Rubenstein, Clinical Professor of Neurology, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, Langone Medical Center, School of Medicine, New York University "Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics." --Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida
Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials.
PART 1 - STUDY TYPE DETERMINATION1. Epidemiological studies 2. Analytical studies 3. Summary PART 2 - OBSERVATIONAL STUDIES 4. Determination of association strength between an exposure factor and an event in observational studies5. Increasing accuracy in observational studies PART 3 - STEP-BY-STEP BIOSTATISTICS OF A CLINICAL TRIAL6. STEP 1: Investigator's hypothesis and expression of its corresponding outcome7. STEP 2: n estimation and n assessment of a published trial8. STEP 3: Organization of variables and endpoints9. STEP 4: Measures for results expression of a clinical trial10. STEP 5: Determination of normality or non-normality of data distribution 11. STEP 6: Hypothesis testing12. STEP 7: Correlating sample data with the general population - 95% confidence Interval PART 4 - ADDITIONAL CONCEPTS IN BIOSTATISTICS13. Individual and collective benefit and risk indexes inferable from intervention cohort studies14. Statistical assessment of diagnostic tests for the clinic15. Systematic reviews and meta-analyses16. Correlation and regression17. Per protocol analysis and intention to treat analysis
Subject Areas: Genetics [non-medical PSAK], Pharmacology [MMG]
