Post-transcriptional Gene Regulation in Human Disease

Offers a deep examination of post-transcriptional gene regulation mechanisms in human disease, from fundamental concepts to research methods and drug targets

Buddhi Prakash Jain (Edited by), Shyamal K Goswami (Edited by), Tapan Sharma (Edited by)

9780323913058, Elsevier Science

Paperback / softback, published 16 August 2022

394 pages, 70 illustrations (30 in full color)
23.5 x 19 x 2.5 cm, 0.81 kg

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

1. Regulation of Gene Expression in Mammals: An Overview
2. Post Transcriptional Gene Regulation: An Overview
3. Methods to Study Post-Transcriptional Regulation of Gene Expression
4. Epigenetic Regulation of Post-Transcriptional Machinery
5. Post-Transcriptional Regulation: A Less Explored Territory in the World of Neurodegenerative Diseases
6. Role of Post-Transcriptional Gene Regulation in Hematological Malignancies
7. Post-Transcriptional Gene Regulation in Solid Tumors
8. A Comprehensive View of the Prostate Cancer Metastasis and Role of Androgen Receptor Splice Variants
9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome
10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their Role in CVDs
11. microRNAs as Critical Regulators in Heart Development and Diseases
12. MicroRNA Regulation in Autoimmune Diseases
13. Post-Transcriptional Regulation of Inflammatory Disorder
14. Post-Transcriptional Gene Regulation in Metabolic Syndrome
15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral and Host Factors
16. Post-Transcriptional Regulation of Gene Expression in Entamoeba histolytica
17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria Parasite Plasmodium falciparum
18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines Anemia of Chronic Diseases
19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder

Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]