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Plant-Derived Neurotherapeutics
Mechanisms and Applications for Brain Health
Mukul Jain (Edited by), Jain (Author), Mohd. Tariq (Edited by), Arifullah Mohammed (Edited by), Ayush Madan (Edited by)
9781394360239, Wiley
Hardback, published 23 June 2026
688 pages
25 x 15 x 1.5 cm, 0.666 kg
Unlock the future of brain health with this evidence-based guide that bridges the gap between traditional herbal medicine and modern neuropharmacology, providing the clinical insights needed to develop next-generation neurotherapeutics. Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s, and mental health conditions like depression and anxiety, are on the rise due to an aging global population, lifestyle factors, and environmental stressors. These conditions often lack effective and sustainable treatment options, creating an urgent need for innovative therapies. The field of plant-derived neurotherapeutics, at the intersection of traditional herbal medicine and modern neuropharmacology, is rapidly emerging as a promising new area of treatment for these disorders. This book offers a comprehensive exploration of the neurotherapeutic potential of plant secondary metabolites by providing an in-depth look at a broad range of plant-derived compounds, including flavonoids, alkaloids, terpenoids, and polyphenols. Through its detailed exploration of how these compounds support brain health, the book offers a foundational understanding of their therapeutic roles within neuropharmacology. It includes real-world case studies and summaries of preclinical and clinical trials, presenting an evidence-based perspective on plant-derived neurotherapeutics. With contributions from experts across neuropharmacology, phytochemistry, and integrative medicine, the book provides an interdisciplinary audience of researchers, clinicians, and students a glimpse into the future of plant-derived compounds in neurotherapeutics.
Preface xxv 1 Introduction to Plant-Derived Neurotherapeutics: An Overview of Secondary Metabolites 1 2 Phytochemistry of Neuroprotective Compounds: Key Classes and Their Properties 47 3 Mechanisms of Action: How Plant Metabolites Interact with Neurological Pathways 97 4 Antioxidant Pathways: Combating Oxidative Stress in the Brain 119 5 Anti-Inflammatory Effects of Plant Metabolites on Neurological Health 155 6 Modulating Neurotransmitter Systems: Plant Compounds in Cognitive Enhancement 189 7 Promoting Neurogenesis and Neuroplasticity: Potential for Brain Regeneration 217 8 Alzheimer's Disease and Phytochemicals: Mechanisms and Potential Treatments 247 9 Parkinson's Disease: Plant Derived Therapeutics and Dopaminergic Support 267 10 Huntington's and Other Neurodegenerative Disorders: Plant-Based Interventions 305 11 Mental Health Disorders: Phytochemical Approaches to Anxiety, Depression, and Stress 343 12 Bioavailability and Pharmacokinetics of Plant Metabolites in Neurotherapeutics 391 13 Formulation and Delivery Systems for Brain-Targeted Phytochemicals 435 14 Preclinical and Clinical Studies: Evidence Supporting Plant Neurotherapeutics 469 15 Plant-Based Brain Therapies: Challenges and Future Prospects Along with Molecular Mechanism Aided in Cognitive Protection 511 16 Traditional and Modern Uses of Plants in Neurotherapy—A Comparative Perspective 561 17 Case Studies of Plant Extracts in Neurotherapeutics Formulations 591 18 Future Trends in Plant-Derived Neurotherapeutics: From Lab to Clinic 609 References 637
Koushik Das, Yukti Mittal, Injamamul Haque and Zuber Khan
Baskaran Gunasekaran, Saema Hanafi, Kirtana Devi and Vaidehi Ulaganathan
Nil Patil, Urvi Patil, Mukul Jain, Ayush Madan and Mohd. Tariq
Annu Verma, D.S.N.B.K. Prasanth and Ashwini Deshpande
Ahmed H. Elosaily, Ahmed M. El-Dessouki, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Ghadir A. Sayed and Noha M. Gamil
Reshma Tendulkar and Mugdha Tendulkar
Vivek Sharma, Tanuja Sharma, Naveen Singh, Rajnish Srivastava and Naresh Kumar Rangra
Shaik Ibrahim Khalivulla, Arifullah Mohammed and Saeed Alshahrani
Naveen Singh, Namita Aggarwal, Nitin Verma and Rajnish Srivastava
Mukul Jain, Rupal Dhariwal, Akangsha Lahon, Ritika Bhardwaj and Krishna Thakkar
Mohd Farhan, Mohd Faisal, Asim Rizvi, Ghazala Muteeb, Mohammad Aatif and Mir Waqas Alam
Himanshu Jain and Neeraj K. Aggarwal
Unmesh Gulabrao Bhamare, Prakash Pannalal Muleva, Deepali Dattatray Bhandari, Ramanlal Narayan Kachave, Sunil Vishvnath Amrutkar and Dattatraya Manohar Shinkar
Nisha Vijayan Kalayil, Sahaya Nadar, Ekta Thakor and Jegan Nadar
K.R. Padma, K.R. Don, M. Sankari, K. Harathi and N. Sandhya
Laxmi, Rahul Sharma, Shriyansh Srivastava, Izaz Hussain and Rakesh Sahu
Erum Khalid, Sudhair Alam, Feroza Hamid Wattoo, Muhammad Javaid Asad, Saima Amin and Muhammad Gulfaraz
Ananda Kumar Chettupalli, Mustapha, S.K. Abdual Rahaman, Neha Gupta, Garlapati Vijay Kumar and Sarad Pawar Naik Bukke
Index 645
Subject Areas: Chemistry [PN]
