Physiological and Clinical Aspects of Short-Chain Fatty Acids

This is the first comprehensive volume to look at the importance of short-chain fatty acids in digestion, the function of the large intestine and their role in human health.

John H. Cummings (Edited by), John L. Rombeau (Edited by), Takashi Sakata (Edited by)

9780521616133, Cambridge University Press

Paperback, published 2 December 2004

596 pages, 92 b/w illus. 46 tables
24.6 x 18.9 x 3.1 cm, 1.05 kg

This is the first comprehensive volume to look at the importance of short-chain fatty acids in digestion, the function of the large intestine and their role in human health. Short-chain fatty acids are the major product of bacterial fermentation of dietary carbohydrates in the human and animal large intestine. They represent the major end products of digestive processes occurring in the caecum and large intestine. As such, they form an important dietary component and it is increasingly recognised that they may have a significant role in protecting against large bowel cancer and in metabolism. Prepared by an international team of contributors who are at the forefront of this area of research, this volume will be an essential source of reference for gastroenterologists, nutritionists and others active in this area.

1. Definitions and history O. M. Wrong
2. Chemistry of short-chain fatty acids (SCFA) M. Fukushima
3. Measurement of acetate by enzymatic methods M. Elia and G. Jennings
4. Biochemistry and microbiology in the rumen R. J. Wallace
5. SCFA in the hindgut G. Breves and K. Stuck
6. Microbiological aspects of SCFA production in the large bowel G. T. Macfarlane and G. R. Gibson
7. Reductive acetogenesis in animal and human gut M. Durand and A. Bernalier
8. Flow dynamics of digesta and colonic fermentation I. D. Hume
9. Transport of SCFA in the ruminant forestomach G. Gäbel
10. Absorption of SCFA from the large intestine W. V. Engelhardt
11. Metabolism of SCFA in the liver C. Rémésy, C. Demigné and C. Morand
12. Effects of SCFA from the large intestine C. Cherbut
13. Sensory mechanisms for SCFA in the colon T. Yajima
14. Effects of SCFA on exocrine and endocrine pancreatic secretion K. Katoh
15. Effect of SCFA on salivary flow in ruminants P. Nørgaard
16. Utilization of volatile fatty acids in ruminants E. R. Ørskov
17. SCFA, pancreatic hormones and appetite control A. de Jong
18. Effects of butyrate on cell proliferation and gene expression J. Kruh, N. Defer and L. Tichonicky
19. Effects of SCFA on gut epithelial cell proliferation in vivo T. Sakata
20. SCFA and colon tumorigenesis J. R. Lupton
21. Butyrate and the human cancer cell G. P. Young and P. R. Gibson
22. The place of SCFAs in coloncyte metabolism in health and ulcerative colitis W. E. W. Roediger
23. Management of diversion colitis, pouchitis and distal ulcerative colitis W. Scheppach, P. Bartram and F. Richter
24. The effects of SCFA on phagocytic cell function G. F. Brisseau and O. D. Rotstein
25. SCFA, antibiotic associated diarrhoea, colonic adenomas and cancer P. B. Mortensen and M. R. Clausen
26. In vivo and in vitro effects of SCFA on intestinal blood circulation F. V. Mortensen and H. Nielsen
27. SCFA and intestinal surgery J. L. Rombeau, K. J. Reilly and R. H. Rolandelli
28. SCFA as an energy source in the colon G. Livesey and M. Elia
29. SCFA and carbohydrate metabolism T. M. S. Wolever
30. SCFA and hepatic lipid metabolism D. L. Topping and I. Pant
31. SCFA and lipid metabolism J. W. Anderson
32. Colonic SCFA in infants and children C. H. Lifschitz
33. Short-chain triglycerides in clinical nutrition S. J. DeMichele and M. D. Karlstad.

Subject Areas: Physiology [MFG]