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Phenotypic Switching
Implications in Biology and Medicine
Provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms and their role in biology and medicine
Herbert Levine (Edited by), Mohit Kumar Jolly (Edited by), Prakash Kulkarni (Edited by), Vidyanand Nanjundiah (Edited by)
9780128179963
Paperback, published 8 June 2020
762 pages, 250 illustrations (200 in full color)
23.4 x 19 x 4.6 cm, 1.56 kg
"This is a very high-quality book that targets a developing area of biological research and fully fleshes it out thanks to excellent authorship. The volume is intended for a fairly narrow and select audience. It provides a comprehensive
overview of the field as it stands today." --Doody
Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.
1. The fundamentals of phenotypic plasticity 2. Rethinking the role of chance in the explanation of cell differentiation 3. Random walk across the epigenetic landscape 4. Maneuvering protein functions and functional levels by structural excursions 5. Prion-mediated phenotypic diversity in fungi 6. Bistability in virus - host interaction networks underlies the succes of hepatitis C treatments 7. Quantifyinh Waddington landscapes, paths, and kinetics of cell fate decision making of differentiation/development 8. The physics of cell fate 9. Disentangling the environmentally induced and stochastic development components of phenotypic variation 10. The evolution of cell differentiation in animals: biomolecular condensates as amplification hubs of inherent cell functions 11. Phenotypic switching and its evolutionary consequences 12. Cell-state organization by exploratory sloppy dynamics 13. Emergence of metabolic heterogeneity in cell populations: lessons from budding yeast 14. Stochastic phenotypic switching in endothelial cell heterogeneity 15. Regulation of phenotypic plasticity from the perspective of evolutionary developmental biology 16. Phenotypic plasticity and the origins of novelty 17. Niche construction and the transition to herbivory: Phenotype switching and the organization of new nutritional modes 18. NAture, nurture, and noise in bird song ontogeny as determinants of phenotypic and functional variation among dialects 19. Domestication as a process generating phenotypic diversity 20. The glycobiology of ovarian cnacer progression: phenotypic switches an microenvironmental influences 21.Epithelia-mesenchymal transition in cancer 22. Phenotypic switching and prostate diseases: a model proposing a causal link benign prostatic hyperplasia and prostate cancer 23. Phenotypic plasticty and lineage switching in prostate cancer 24. Implications of non-genetic heterogeneity in cancer drug resistance and malignant progression 25. Phenotypic plasticity: the emergence of cancer stem cells and collective cell migration 26. Adaptive phenotypic switching in breast cancer in response to matric deprivation 27. Phenotypic instability induced by tissue disuption at the origin of cancer 28. Evolutionary strategies to overcome cancer cell resistance ot treatment
Subject Areas: DNA & Genome [PSAK1], Genetics [non-medical PSAK]
