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Pharmacogenetics and Individualized Therapy
Anke-Hilse Maitland-van der Zee (Edited by), Maitland–van de (Author), Ann K. Daly (Edited by)
9780470433546, Wiley
Hardback, published 25 May 2012
520 pages
24.1 x 16.3 x 3 cm, 0.848 kg
“This is a well-written book that I highly recommend to anyone interested in any aspect of personalized medicine.” (Doody’s, 24 August 2012)
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Preface vii Contributors ix 1. Pharmacogenetics: A Historical Perspective 1 Part I Pharmacogenetics: Relationship to Pharmacokinetics and Pharmacodynamics 2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15 3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81 4. Pharmacogenetics of Drug Transporters 101 5. Pharmacogenetics of Drug Targets 149 Part II Pharmacogenetics: Therapeutic Areas 6. Cardiovascular Pharmacogenetics 185 7. Pharmacogenetics in Psychiatry 215 8. Pharmacogenetics in Cancer 251 9. Pharmacogenetics of Asthma and COPD 271 10. Pharmacogenetics of Adverse Drug Reactions 295 11. Pharmacogenomics of Inflammatory Bowel Diseases 323 12. Pharmacogenetics of Pain Medication 353 Part III Pharmacogenetics: Implementation in Clinical Practice 13. Ethical and Social Issues in Pharmacogenomics Testing 377 Part IV Developments in Pharmacogenetic Research 14. High-Throughput Genotyping Technologies for Pharmacogenetics 403 15. Developments in Analyses in Pharmacogenetic Datasets 415 Part V Pharmacogenetics: Industry and Regulatory Affairs 16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 439 17. Role of Pharmacogenetics in Registration Processes 461 Part VI Conclusions 18. Pharmacogenetics: Possibilities and Pitfalls 479 Index 485
Ann K. Daly
Vita Dolan
Ingolf Cascorbi
Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer
Ann K. Daly and Maria Arranz
Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke-Hilse Maitland-van der Zee
Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K. Daly
Sharon Marsh
Ellen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and Gerard H. Koppelman
Ann K. Daly, Martin Armstrong, and Munir Pirmohamed
Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab
Jörn Lötsch
Susanne Vijverberg, Toine Pieters, and Martina Cornel
Beatriz Sobrino and Angel Carracedo
Alison A. Motsinger-Reif
Daniel K. Burns and Scott S. Sundseth
Myong-Jin Kim, Issam Zineh, Shiew-Mei Huang, and Lawrence J. Lesko
Anke-Hilse Maitland-van der Zee and Ann K. Daly
Subject Areas: Chemistry [PN]
