Phagocytosis of Bacteria and Bacterial Pathogenicity

Research overview of the mechanisms of phagocytosis and how pathogenic bacteria avoid or exploit them.

Joel D. Ernst (Edited by), Olle Stendahl (Edited by)

9780521845694, Cambridge University Press

Hardback, published 7 September 2006

296 pages, 33 b/w illus. 8 colour illus.
23.5 x 15.8 x 1.9 cm, 0.616 kg

“Phagocytosis of Bacteria and Bacterial Pathogenicity gives a concise and coherent view of the molecular complexity and beautiful diversity of the phagocytic process of pathogenic bacteria. This book will be a useful reference for students and professionals of immunology, inflammation, infections diseases, and microbiology.” Andres Vazquez-Torres, Department of Microbiology, University of Colorado Health Sciences Center School of Medicine at Fitzsimons, Aurora, Colorado

This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.

1. Introduction Olle Stendahl
2. Phagocytosis: receptors and biology Wouter L. W. Hazenbos and Eric J. Brown
3. Receptor-initiated signal transduction during phagocytosis Kassidy K. Huynh and Sergio Grinstein
4. Life, death, and inflammation: manipulation of phagocyte function by Helicobacter pylori Lee-Ann H. Allen
5. Phagocytosis of Streptococcus pneumoniae Dominic L. Jack, David H. Dockrell, Stephen B. Gordon and Robert C. Read
6. Yersinia inhibition of phagocytosis Maria Fällman and Anna Gustavsson
7. Listeria invasion and spread in nonprofessional phagocytes Frederick S. Southwick
8. Mycobacterium tuberculosis: mechanisms of phagocytosis and intracellular survival Joel D. Ernst and Andrea Wolf.

Subject Areas: Bacteriology [non-medical PSGD], Microbiology [non-medical PSG], Biochemical immunology [PSBM], Immunology [MJCM]