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Perspectives on the Human Genome Project and Genomics Volume 24
Christopher R. Donohue (Edited by), Alan C. Love (Edited by)
9781517921026
Paperback / softback, published 21 July 2026
600 pages, 20 black & white illustrations, 3 tables
22.9 x 15.2 x 3.2 cm, 0.907 kg
Interdisciplinary voices reflect on some of the most complex and consequential scientific undertakings of our time Coeditors Christopher R. Donohue and Alan C. Love bring together a range of perspectives on the HGP's progress and legacy, as well as other major genomics projects, to explore not only their scientific achievements but also their social and political dimensions. Presenting reflections from historians, philosophers, and sociologists alongside those of key NHGRI scientists like Eric Green, Mark Guyer, and Elise Feingold; experts like Nature editor-in-chief Magdalena Skipper and geneticist Eric Vilain; and scholars of the ethical, legal, and social implications of genomics like Jean McEwan and Joy Boyer, Perspectives on the Human Genome Project and Genomics highlights the international, interdisciplinary collaborations and collective long view that underpinned these genomics initiatives aimed at a better understanding of our basic biology and genetic diseases. From genomic variation and sequencing technologies to the integration of big data and the influence of ancestry and gender, this book is an essential resource for deepening the discussion of the scientific, historical, and ethical impacts of genomics and a fascinating collection of insights into coordinated science in the making. Contributors: Rina Bliss, Joy Boyer, Lisa D. Brooks, Michel Dubois, Elise A. Feingold, Adam Felsenfeld, Miguel García-Sancho, Eric D. Green, Catherine Guaspare, Chris Gunter, Stephan Guttinger, Mark Guyer, Elke Jordan, Jonathan E. LoTempio Jr., Jean McEwen, Jane Peterson, Anya Plutynski, Ramya M. Rajagopalan, Emanuele Ratti, Sahotra Sarkar, Jeffery A. Schloss, Magdalena Skipper, Alexandra Soulier, Thomas Stoeger, Eric Vilain, Kris A. Wetterstrand. Retail e-book files for this title are screen-reader friendly with images accompanied by short alt text and/or extended descriptions.
Perspectives on the Human Genome Project and Genomics is a groundbreaking volume that examines the pivotal roles of the National Institutes of Health (NIH) and the National Human Genome Research Institute (NHGRI) in the Human Genome Project (HGP) and the development of other major genomics projects. Drawing on newly uncovered archival materials and oral histories from NHGRI, this volume offers a multifaceted narrative of transformative scientific achievements of the twentieth and twenty-first centuries.
Contents Preface Eric D. Green List of Abbreviations Introduction: Complexity, Contingency, and Controversy in Genomics Christopher R. Donohue and Alan C. Love Part I. Producing the Genome 1. Challenges in the Early Years of the Human Genome Project at the National Institutes of Health: A Personal Retrospective Elke Jordan 2. Unsung Contributors to the Human Genome Project: NIH Staff and Advisors Mark Guyer, Kris A. Wetterstrand, and Jane Peterson 3. The NHGRI Genome Sequencing Cost Curve: An Indicator of Scientific Progress Kris A. Wetterstrand and Jonathan E. LoTempio Jr. 4. History of the Encyclopedia of DNA Elements (ENCODE) Project Elise A. Feingold 5. NHGRI Genetic Variation Program Lisa D. Brooks 6. Genome Technology Development Grants for the Human Genome Project and Beyond Jeffrey A. Schloss Part II. Contextualizing the Genome 7. The Nature of Genomic Publishing Chris Gunter and Magdalena Skipper 8. Europe and the Genome: An Overlooked Strategy for a Translational Genomics Miguel García‐Sancho 9. Technological Change Driving Scientific Questions: Genomic Sequencing as a Case Study Adam Felsenfeld and Kris A. Wetterstrand 10. Addressing Ethical, Legal, and Social Implications (ELSI): Navigating Ongoing Productive Tensions Joy Boyer and Jean McEwen 11. "Variations on a Theme": A History of Errors and Polymorphisms in the Human Genome Project and Beyond Christopher R. Donohue 12. Transforming the Genome into a Clinical Resource: DNA, Data, and Algorithms in Medicine Ramya M. Rajagopalan Part III. Interpreting the Genome 13. The Difference Genomics Makes: Characterizing Human Differences After the Human Genome Project Rina Bliss 14. The Trouble with Being "Socially Responsible": Science, GWAS, and Sexual Orientation Michel Dubois, Catherine Guaspare, and Eric Vilain 15. Epigenetics in Public Health: Comments on the "From Cells to Society" Approach Alexandra Soulier 16. When Eugenic Enhancement Meets the Myth of Genetic Reductionism Sahotra Sarkar 17. modENCODE and the Elaboration of Functional Genomic Methodology Stephan Guttinger and Alan C. Love 18. The Cancer Genome Atlas Project: Data-Driven, Hypothesis-Driven, or Something In-Between? Anya Plutynski 19. Large-Scale Biology: Philosophical, Historical, and Computational Perspectives Emanuele Ratti and Thomas Stoeger Contributors Index