Perspectives on Lung Endothelial Barrier Function

C.E. Patterson (Author), Edward Bittar (Series edited by)

9780444518347

Hardback, published 9 December 2004

540 pages
22.9 x 15.1 x 3.1 cm, 1.1 kg

This readable, comprehensive text covers endothelial biology from the fundamentals of structure and lung fluid balance physiology to state-of-the-art descriptions of the molecular mechanisms involved in the development of lung failure. The material and illustrations, provided by outstanding experts in their individual areas of research and clinical concentration, is artfully woven together to provide the reader with an integrated, in-depth, and up-to-date knowledge of endothelial function, vascular integrity, pulmonary function, and pathophysiology in respiratory failure.

The cellular and molecular foundations of pulmonary edema
Molecular architecture of endothelium
The activated endothelial cell phenotypes
Membrane and cellular signaling of integrity and acute activation
Adenylyl cyclase and camp regulation of the endothelial barrier
Signaling of prolonged activation
Dynamic microfilaments and microtubules regulate endothelial function
Endothelial-matrix interactions in the lung
Interendothelial junctions and barrier integrity
Heterogeneity of lung endothelial cells
Interaction of endothelial cells with blood elements
Endothelial cell injury and defense
Endothelial injury due to infectious agents
Chronic lung vascular hyperpermeability
Advances in protection of endothelial barrier function
Looking to the future as keepers of the dam.

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Biology, life sciences [PS], Physiology [MFG]