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Personalizing Precision Medicine
A Global Voyage from Vision to Reality
Kristin Ciriello Pothier (Author)
9781118792117, Wiley
Paperback / softback, published 13 October 2017
272 pages
22.6 x 14.7 x 1.5 cm, 0.431 kg
“A tour de force - Kristin brings Precision Medicine into focus with clear and practical commentary. Personalizing Precision Medicine is exactly what healthcare establishment needs now - how to make it real and cost effective.” – Mara Aspinall, President and CEO, Health Catalysts, Co-Founder, Arizona State University School of Biomedical Diagnostics “As a surgeon, I find the importance of precision surgery to be obvious, but describing precision medicine has been a challenge – until now! Kristin explains it all, from the basic science to compelling, personal stories that make the science come to life. It helps us examine precision medicine from all angles and helps us as physicians explain it comprehensively to others.” – Tenley Albright, Director of the MIT Collaborative Initiatives, former surgeon, and World and Olympic Champion figure skater
“As a young patient with breast cancer, it was overwhelming to research every aspect of my care to make sure it was personalized for me. This book, Personalizing Precision Medicine, should be one of the very first tools to educate people like me, and those professionals who supported me. The facts, mixed with personal stories from all around the world, were something I wish I’d had when I was first diagnosed.” – Liz Lord, Breast cancer slayer, former US diplomat and owner of ArlVa Homes LLC
The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide.
Acknowledgments vii Introduction ix Methodology xiii About the Author xv Part 1 The History 1 1 The Right Drug, the Right Patient, the Right Time: Foundations of Precision Medicine 3 2 Decision‐Making Machines: Diagnostics in Precision Medicine 27 3 Precision Medicine around the World: Europe 37 Part 2 The Present 51 4 Our Reality Today: The Patient Journey in Precision Medicine 53 5 Toward the Day We Just Call It “Medicine”: Access to Precision Medicine 65 6 Precision Medicine around the World: Japan 81 7 Shifting Rules: Regulation and Reimbursement in Precision Medicine 89 8 Precision Medicine around the World: Latin America 105 9 Patients as the Poorest Princesses: Supportive Care in Precision Medicine 125 10 Informatics under the Hood: Information in Precision Medicine 135 11 Precision Medicine around the World: India 149 Part 3 The Future 157 12 A Personalized Stomach: Precision Medicine beyond Cancer 159 13 Consumer is King: Consumer Applications of Precision Medicine 181 14 Precision Medicine around the World: The Middle East 197 15 Sci‐Fi Potential: CRISPR as the Next Novel Frontier in Precision Medicine 207 16 Precision Medicine around the World: China 223 17 A New Hope: The Future of Precision Medicine 231 Afterword 241 Index 243
Subject Areas: Chemistry [PN]
