Perfusion Cell Culture Processes for Biopharmaceuticals
Process Development, Design, and Scale-up

Master the design and operation of perfusion cell cultures with this authoritative reference.

Moritz Wolf (Author), Jean-Marc Bielser (Author), Massimo Morbidelli (Author)

9781108480031, Cambridge University Press

Hardback, published 6 August 2020

216 pages, 30 b/w illus. 55 colour illus.
25 x 17.5 x 1.5 cm, 0.55 kg

'A delightful guide full of important information for those of us who want to make perfusion great again thanks to the appearance of new cell retention technologies, single use bioreactors and sensors. It will greatly help biotech developers to better understand the fundamentals of cell culture in perfusion, to design appropriately their systems and to control optimally their processes in order to deliver high quality product at a better cost efficiency than the classical large-scale fed-batch processes.' Hervé Broly, Biotech Process Sciences

Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.

1. Perfusion mammalian cell culture for recombinant protein manufacturing
2. Perfusion bioreactors
3. Scale-down models and sensors for process development
4. Design and optimization of mammalian cell perfusion cultures
5. Clinical and commercial-scale reactors
6. Mechanistic and statistical modeling of bioprocesses.

Subject Areas: Chemical engineering [TDCB], Biotechnology [TCB], Molecular biology [PSD], Optimization [PBU], Biomedical engineering [MQW], Pharmacology [MMG], Biotechnology industries [KNDH1], Food manufacturing & related industries [KNDF]