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Patient Derived Tumor Xenograft Models
Promise, Potential and Practice
Presents current guidance on the proper selection of immunodeficient strains, methodologies, and the care of PDX models, including data interpretation tactics
Rajesh Uthamanthil (Edited by), Peggy Tinkey (Edited by), Elisa de Stanchina (Edited by)
9780128040102
Paperback / softback, published 2 November 2016
486 pages
22.9 x 15.1 x 3 cm, 0.72 kg
Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory.
Section I. Mouse Xenograft Models of Cancer Chapter 1. PDX Models: History and Development Chapter 2. History of Mouse Cancer Models Chapter 3. Challenges and Limitations of Mouse Xenograft Models of Cancer Chapter 4. Tumor Heterogeneity Chapter 5. Immunodeficient Mice: The Backbone of Patient-Derived Tumor Xenograft Models Chapter 6. Humanized Mice and PDX Models Section II. Components of a PDX Program Chapter 1. Regulations of Patient-Derived Xenografts Chapter 2. Acquisition and Storage of Clinical Samples to Establish PDX Models Chapter 3. Methodologies for Developing and Maintaining Patient-Derived Xenograft Mouse Models Chapter 4. Pathology of Patient-Derived Xenograft Tumors Chapter 5. Genetic Profiling of Tumors in PDX Models Chapter 6. Running a PDX Core Laboratory or a PDX Support Program Chapter 7. Veterinary Care Chapter 8. Occupational Health and Safety Section III. PDX Models for Tumors of Various Organ Systems Chapter 1. Pediatric and Adult Brain Tumor PDX Models Chapter 2. Patient-Derived Xenograft Models of Prostate Tumors Chapter 3. Patient-Derived Xenograft Model of Pancreatic Cancer Chapter 4. Modeling Breast Cancer Heterogeneity With Patient-Derived Xenografts Chapter 5. Patient-Derived Xenograft Models of Ovarian/Gynecologic Tumors Chapter 6. Patient-Derived Xenografts From Lung Cancer and Their Potential Applications Chapter 7. PDX Models of Colorectal Tumors Chapter 8. Patient-Derived Tumor Xenografts in Hematologic Disorders Chapter 9. Patient-Derived Xenografting of Human Melanoma Chapter 10. Advances in Organoid Culturing of Patient-Derived Tumors Section IV. PDX Models in Cancer Research and Therapy Around the World Chapter 1. Global Practices in PDX Programs Chapter 2. Role of Companies and Corporations in the Development and Utilization of PDX Models Section V. Challenges & Future of PDX Models Chapter 1. Patient-Derived Tumor Xenograft: Present and Future Challenges and Applications
Subject Areas: Veterinary surgery [MZS], Surgery [MN], Pharmacology [MMG], Oncology [MJCL], Clinical trials [MBGR1]
