About the Editors xi

About the Associate Editors xiii

List of Contributors xv

Preface to the Fifth Edition xxiv

Preface to the Sixth Edition xxv

Foreword xxvi

Introduction: Historical perspectives 1
Michael J. Denham and John E. Morley

Part 1 | Ageing: Biological, Social, and Community Perspectives

1 A biological perspective of ageing 13
Florent Guerville and Maël Lemoine

2 Physiology of ageing 22
Sevnaz Şahin and Emin Taskiran

3 Psychological aspects of ageing 34
Evan T. Schulze, Phillip Ruppert, Gayle Heady, and Lauren Schwarz

4 Social and community aspects of ageing 43
Kahli E. Zietlow and Serena P. Wong

5 Sexuality and ageing 59
Serena P. Wong and Kahli E. Zietlow

6 Ageing of the brain 68
Marco Canevelli and Luca Marsili

7 Physical fitness and exercise 77
Maria A. Fiatarone Singh, Mikel Izquierdo, and John E. Morley

8 Health literacy and cultural sensitivity 108
Nina Tumosa

Part 2 | Medicine and Prescribing in Old Age

9 Preventive geriatrics 121
Gerald M. Mahon, Suzanne M. Mahon, and Joseph H. Flaherty

10 Polypharmacy and deprescribing in older adults 132
Fernanda Heitor and Milta Little

11 Patient safety 146
Katherine Evans, Nandkishor Athavale, Susannah Long, and Charles Vincent

Section 1 Eating Disorders and Nutritional Health

12 Nutrition and healthy ageing: Emphasis on brain, bone, and muscle 167
Gene L. Bowman

13 The anorexia of aging 177
Neema Sharda, Jantira Thomas, and Ian M. Chapman

14 Weight loss 190
Isabelle Bourdel‐Marchasson and David R. Thomas

15 Water and electrolyte balances in ageing 202
Stewart G. Albert and Alexis McKee

16 Vitamins and minerals 213
Mary Ann Johnson and Connie W. Bales

Section 2 Gastro Disorders

17 Changes in gastrointestinal motor and sensory function associated with ageing 231
Christopher K. Rayner and Michael Horowitz

18 The liver and gallbladder in the geriatric population 247
Gary Trey

19 Faecal incontinence 254
William Gibson

20 Constipation 263
Katherine A. Evans and Charlene M. Prather

21 Diseases of the pancreas 274
Tyler M. Berzin and Awais Ahmed

Section 3 Haematological Disorders

22 Anaemia in older people 283
Angela M. Sanford

23 Disseminated intravascular coagulation 294
Kingsley K. Hampton

24 Disorders of haemostasis 298
Kingsley K. Hampton

25 When to anticoagulate, and which anticoagulant? 307
Irene Criado Martin, Alba Mª Costa Grille, and Roberto Petidier Torregrossa

26 Myelodysplasia 316
Domenico Fusco, Andrea Bellieni, Beatrice Di Capua, and Giuseppe Colloca

27 Management of myelodysplastic syndromes and acute myeloid leukaemias in the elderly 331
Delphine Bréchemier, Marie Garric, and Thomas De Nadaï

Section 4 Cardiovascular Diseases and Health

28 Epidemiology of heart disease 345
Marco Proietti

29 Arrhythmias 360
C. Fielder Camm and A. John Camm

30 Ischaemic heart disease 388
Ahmed H. Abdelhafiz

31 Lipid management 400
Tiziano Lucchi

32 Hypotension 419
Elspeth A. Clark and Gwendolen T. Buhr

33 Hypertension in older people 427
Ahmed H. Abdelhafiz and Alan J. Sinclair

34 Heart failure 439
Nandkishor V. Athavale

35 Cardiac surgery and percutaneous interventions in the elderly 455
Ulrich von Oppell, Adam Szafranek, and Richard Anderson

36 Peripheral arterial disease 482
Leocadio Rodríguez Mañas, Marta Castro Rodríguez, and Cristina Alonso Bouzón

37 Venous thromboembolism in the elderly 493
Alessandra Bura‐Riviere, Lucas Verset, and François‐Xavier Lapebie

Section 5 Respiratory Diseases

38 Epidemiologic and pathophysiologic overview of respiratory infections 501
Sean D. Levy and Ronald C. Silvestri

39 Pneumonia 512
Joël Belmin

40 Aspiration pneumonia 522
Ben Blomberg and Neema Sharda

41 The COVID‐19 pandemic in older people 530
Nandkishor V. Athavale, Joanne Conway, Demelza Emmerton, and Ahmed H. Abdelhafiz

42 Chronic obstructive pulmonary disease and asthma 542
Simone Scarlata and Raffaele Antonelli Incalzi

43 Pulmonary rehabilitation 555
Mangalore Amith Shenoy and Peter Spiegler

Section 6 CNS Disorders

44 Neurological signs of ageing 563
Jonathan M. Schott and Andrew J. Larner

45 Sleep apnoea and sleep disorders 570
Araceli Abad, Cristina Matesanz, Carmen Acosta, and Cristina López

46 Normal pressure hydrocephalus 581
Vito Curiale and Sandrine Louchart De La Chappelle

47 Acute stroke care and management of carotid artery stenosis 598
David Doig and Martin M. Brown

48 Stroke and stroke rehabilitation 619
Guillaume Albaret and Helene Domergue

49 Communication disorders and dysphagia 635
Pamela M. Enderby

50 Acute and chronic subdural hematoma 644
Lauren Peruski and Magdy Selim

51 Epilepsy 653
Almudena Areosa Sastre and Irene Lozano Rosique

52 Syncope and non‐epileptic attacks 664
Matteo Cesari and Beatrice Arosio

53 Parkinson’s disease 674
Bruno Oquendo and Joël Belmin

54 Non‐Parkinsonian movement disorders in the elderly 681
Christian Johannes Amlang and Katie Kompoliti

55 Diabetic neuropathy 698
Ahmed H. Abdelhafiz and Alan J. Sinclair

56 Disorders of the neuromuscular junction 709
Sivakumar Sathasivam and Andrew J. Larner

57 Muscle disorders 718
Devyani Misra

58 Motor neuron disease 733
Pascal Cintas

59 Chronic pain 743
Benny Katz

60 Multiple sclerosis 756
Krupa S. Pandey and Florian P. Thomas

Appendix Function assessment scales i

Index xvii

Contents of Volume 2

About the Editors xi

About the Associate Editors xiii

List of Contributors xv

Preface to the Fifth Edition xxiv

Preface to the Sixth Edition xxv

Foreword xxvi

Section 7 Dementia and Cognitive Disorders

61 Delirium in older patients 771
Sarah A. Wingfield and Joseph H. Flaherty

62 Memory clinics 782
Ipsit V. Vahia

63 Alzheimer’s disease 794
Julien Delrieu

64 Mild cognitive impairment: an update 808
Pierre- Jean Ousset

65 Vascular dementia 811
Marco Inzitari and Domenico Inzitari

66 Mental stimulation and dementia 822
Joe Verghese

67 Exercise and dementia 829
Yves Rolland and Philipe de Souto Barreto

68 Drug development and Alzheimer’s disease 843
Julien Delrieu and Bruno Vellas

69 Other dementias 860
Wee Shiong Lim

70 Management of neuropsychiatric symptoms in dementia 878
Maria Soto Martin and Adelaïde de Mauleon

71 Late- life depression 892
Didi Rhebergen and Max Stek

72 Geriatric psychiatry 904
Abhilash K. Desai and George T. Grossberg

73 Organisation of services in geriatric psychiatry 919
Susan Mary Benbow and Sharmi Bhattacharyya

74 The older patient with Down syndrome 934
John E. Morley

Section 8 Special Senses, Bone, and Joint Health

75 Disorders of the vestibular system 943
Charlotte Ågrup and Linda M. Luxon

76 Smell and taste 957
Eva Topinkova

77 Osteoporosis: burden, diagnosis, and management 972
Jean- Yves Reginster and Olivier Bruyere

78 Gait, balance, and falls 979
Sarah D. Berry and Deborah S. Lee

79 Hip fracture and orthogeriatrics 992
Christine Lafont and Thomas Krams

80 Foot problems 1007
Hylton B. Menz

Section 9 Endocrine and Metabolic Disorders

81 Endocrinology of ageing 1021
Ray Bourey, John Morley, and Alexis McKee

82 The pituitary gland, 1032
Alexis M. McKee and John E. Morley

83 Thyroid disorders 1041
Ligia J. Dominguez and Mario Barbagallo

84 Ovarian function and menopause 1059
Andrea Martínez- Massa, Antonio Marín- Montes, Jorge Abril- Pérez, and Antonio Cano

85 Testicular function 1073
Sandeep Dhindsa

86 Diabetes mellitus 1086
Alan J. Sinclair and Graydon S. Meneilly

87 New therapies for diabetes mellitus 1108
Michelangela Barbieri, Vittoria Cataldo, George T. Griffing, and Giuseppe Paolisso

Section 10 Urogenital Disorders

88 Gynaecology and the older patient 1125
Vishnu Priya Padmanabhan, Susan Joseph, Radha Indusekhar, and Fidelma O’Mahony

89 Prostate diseases 1136
Stephane Gerard, Loic Mourey, Marguerite Briand, Boris Delaunay, and Laurent Balardy

90 The ageing bladder 1153
Matteo Cesari and Beatrice Arosio

91 Geriatric nephrology 1162
David Schlientz, Liza Genao, Carlos G. Musso, and Dimitrios G. Oreopoulos

Section 11 Cancer

92 Cancer and ageing 1171
Ahmed Abdelhafiz

93 Oncological emergencies 1184
Thomas De Nadaï, Chantal Bernard- Marty, Clément Gaudin, and Laurent Balardy

94 Breast cancer 1196
Hannah Chapman

95 Maintaining functional status among older adult cancer patients and survivors 1208
Miriam B. Rodin

Section 12 Functional Disorders and Rehabilitation

96 Multidimensional geriatric assessment 1231
Leocadio Rodríguez Mañas, Marta Castro Rodríguez, Laurence Z. Rubenstein, and Andreas E. Stuck

97 Frailty 1242
Angela M. Sanford and John E. Morley

98 Rehabilitation 1249
Matthew T. Corey

99 Cachexia 1265
Emanuele Marzetti, Anna Picca, Anita Maria Tummolo, and Riccardo Calvani

100 WHO Integrated Care for Older People (ICOPE) 1272
Catherine Takeda, Sophie Guyonnet, Bruno Vellas, and Yuka Sumi

Section 13 Iatrogenic Infections

101 Valvular heart disease and infective endocarditis 1283
Ariane M. Fraiche, Jason D. Matos, and Eli V. Gelfand

102 Infections of the central nervous system 1305
Rodrigo Hasbun

Section 14 Special Issues I Abuse and Older People

I Abuse and Older People

103 Good quality care: abuse 1331
Jean- Pierre Aquino and Laëtitia Ngatcha Ribert

104 Alcohol consumption and cognition 1336
Julien Delrieu, Luc Letenneur, and Jean- François Dartigues

105 The use and abuse of prescribed medicines 1342
Matteo Cesari and Beatrice Arosio

106 Drug misuse and the older person: a contradiction in terms? 1349
Antoine Piau and Fati Nourhashemi

II Emerging Themes

107 Transportation, driving, and older adults 1361
Desmond O’Neill and David Carr

108 Smart Homes 1370
Rodrigo Pérez- Rodríguez

109 Modern use of biomarkers in geriatric medicine 1380
Stefan Walter

III Dermatology

110 Geriatric dermatology 1395
Elizabeth L. Bisbee, Claudia I. Vidal, and Tricia A. Missall

111 Pressure injuries: prevention and management 1403
Madhuri Reddy

IV Surgical Themes

112 Perioperative medical assessment of older adults 1409
Milta Oyola Little, Shelley McDonald, David Schlientz, and Yoon Hie Kim

113 Anaesthesia 1421
Coilin Collins- Smyth and Suzanne Crowe

V Ageing Themes and Ethical Issues

114 Health issues in the ageing woman 1435
Reshma A. Merchant

115 Antiageing strategies 1442
Ligia J. Dominguez and Mario Barbagallo

116 The ethics of geriatric care 1459
Alessandro Blasimme

117 Participation of older people in clinical trials 1466
Nicola Coley and Sandrine Andrieu

118 Restraints and immobility 1478
Katerina Melino, Laura M. Wagner, and Elizabeth A. Capezuti

119 Centenarians 1492
Evelyn Ferri, Marco Proietti, Matteo Cesari, and Beatrice Arosio

120 End- of- life and palliative care 1503
Kate Lally and Rachelle E. Bernacki

121 End- of- life care: special issues 1514
Trisha Dunning

Part 3 | Global Healthcare Systems

122 Improving quality of care 1529
Julie K. Gammack, Babatunde Olumide, and Carolyn D. Philpot

123 Clinical audit of healthcare 1543
Matthew Roycroft

124 Caring for the caregiver 1552
Danielle L. Boisvert, Max Zubatsky, and Marla Berg- Weger

125 Nursing home care 1560
Cari Levy, Briony Jain, Edward Cheong, Lyndal Bugeja, Joseph Ibrahim, Kate Magid, and Emily Galenbeck

126 Geriatric occupational therapy: achieving quality in daily living 1574
Jeremy Whyman

127 Geriatric medicine education in Europe and the United States 1585
Antonio Cherubini, Jesús Mateos- Nozal, Daphne T. Lo, and Miguel A. Paniagua

128 Systems of healthcare: the United States 1594
Julie K. Gammack and Stephanie L. Simpson

129 Systems of healthcare: Australia 1603
Gideon A. Caplan and Taylor A. Scott

130 Systems of healthcare: the UK 1609
Richard Wilson and Simon Conroy

131 Geriatric medicine in China 1616
Woo Jean

132 Ageing in developing countries 1620
Luis Miguel Gutierrez Robledo and Renato Maia Guimarães

133 Geriatric medicine in the European Union: towards unification of diversity 1629
Jesús Mateos- Nozal and Alfonso J. Cruz- Jentoft

134 Research horizons for the twenty- first century 1635
Leocadio Rodríguez Mañas, Miriam El Assar, and Javier Angulo

Appendix Function assessment scales i

Index xvii