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Pathway Analysis for Drug Discovery
Computational Infrastructure and Applications

Anton Yuryev (Edited by), A Yuryev (Author), Sean Ekins (Series edited by)

9780470107058, Wiley

Hardback, published 17 October 2008

336 pages
24.1 x 16.1 x 2.2 cm, 0.617 kg

"Pathway analysis will help lead to a better understanding of the chemistry of living systems and the aberrations that disrupt health. This new book will serve as a beacon to research interested in this field." (Journal of Medicinal Chemistry, April 9, 2009)

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Preface vii

Contributors ix

1 Introduction to Pathway Analysis 1
Anton Yuryev

2 Software Infrastructure and Data Model for Pathway Analysis 27
Fedor Bokov and Anton Yuryev

3 Automatic Pathway Inference in Heterogeneous Biological Association Networks 47
Anton Yuryev, Andrey Kalinin, and Nikolai Daraselia

4 Algorithmic Basis for Pathway Visualization 67
Sergey Simakov, Iaroslav Ispolatov, Sergei Maslov, and Alexander Nikitin

5 Pathway Analysis of High-Throughput Experimental Data 103
Andrey Y. Sivachenko

6 Integrative Pathway Analysis of Disease Molecular Data 121
Andrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and Tatiana Nikolskaya

7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways,Potential Targets, and Noise 149
John Farley, Laurent L. Ozbun, and Michael J. Birrer

8 Mammalian Proteome and Toxicant Network Analysis 165
Sean Ekins and Craig N. Giroux

9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an IllustrativeExample 195
Mark P. Kühnel, Bojana Cosovic, Goran Medic, Robert B. Russell, and Gordana Apic

10 Impact of Chemistry Information on Pathway Analysis 219
Sreenivas Devidas

11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks 237
Sergei Maslov and Iaroslav Ispolatov

12 An Adaptive System Model of the Yeast Glucose Sensor System 263
Todor Vujasinovic and André Siniša Žampera

13 Present and Future of Pathway Analysis in Drug Discovery 285
Anton Yuryev

Index 297

Subject Areas: Chemistry [PN]
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