Paternal Influences on Human Reproductive Success

The only book focussing on the growing understanding of paternal contributions to the embryo and its health.

Douglas T. Carrell (Edited by)

9781107024489, Cambridge University Press

Hardback, published 11 April 2013

204 pages, 30 b/w illus. 19 colour illus.
25.3 x 19.2 x 1.5 cm, 0.65 kg

Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides 'cutting edge' data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis.

Preface
Part I. Advances in Understanding the Male Gamete: 1. The reproductive fitness of the human male gamete Douglas T. Carrell
2. The sperm genome: effect of aneuploidies, structural variations, single nucleotide changes and DNA damage on embryogenesis and development Kenneth I. Aston and Donald F. Conrad
3. The sperm epigenome: a role in embryogenesis and fetal health? Douglas T. Carrell and Jessie Dorais
4. Imprinted gene anomalies in sperm C. Joana Marques and Mário Sousa
5. Has the renewed interest in sperm RNA led to fresh insights? A critical review and hypothesis David Miller and David Iles
6. The role of the sperm centrosome in reproductive fitness Heide Schatten and Qing-Yuan Sun
Part II. The Influence of Aging and Environmental Factors on Male Reproductive Fitness: 7. The male biological clock Harry Fisch
8. The role of aging on fecundity in the male Csilla Krausz and Chiara Chianese
9. Aging, DNA damage, and reproductive outcome Aleksander Giwercman and Jens Peter Bonde
10. Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer Simon L. Conti and Michael L. Eisenberg
11. Sexual function in the aging male John R. Gannon, Jeremy B. Myers and William O. Brant
12. Supplements and replacement therapies for the aging male and their effects on reproductive fitness Armand Zini and Naif Al-hathal
13. Environment and lifestyle effects on fertility Marc A. Beal and Christopher M. Somers
14. Obesity and male infertility: is there an effect on embryogenesis? Oumar Kuzbari and Ahmad O. Hammoud
Part III. Clinical Laboratory Concepts and Considerations: 15. ICSI: does the sperm matter? Gianpiero D. Palermo, Queenie V. Neri and Zev Rosenwaks
16. Sperm selection and ART outcome: a means to overcome the effects of aging and abnormal spermatogenesis? Denny Sakkas
17. Variability of human semen quality: caution in interpreting semen analysis data Kenneth I. Aston
18. Semen characteristics and aging: technical considerations regarding variability Lars Björndahl
Index.

Subject Areas: Paediatric medicine [MJW], Materno-fetal medicine [MJTF], Gynaecology & obstetrics [MJT]