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Oxidative Stress
Its Mechanisms and Impacts on Human Health and Disease Onset
Covers oxidative stress and its implications in human disease, describing mechanisms of disease induction and how the Oxidative Stress Index is used
Harold Zeliger (Author)
9780323918909, Elsevier Science
Paperback / softback, published 26 October 2022
500 pages, 100 illustrations (10 in full color)
23.5 x 19 x 3.1 cm, 1.02 kg
Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.
I. Oxidative Stress and Disease 1. Oxidative stress causes 2. Historical perspective 3. Chemicals and chemical mixtures 4. Particles and fibers 5. Air pollution 6. Alcohol, tobacco and recreational drug use 7. Radiation 8. Chronic inflammation 9. Chronic Trauma 10. Dietary choices 11. Sleep deprivation 12. Hot and cold Environmental temperature extremes 13. Pre-existing disease 14. Pharmaceutical drugs 15. Chronic psychological stress 16. Genetic and epigenetic factors II. Mechanism of Disease Onset 17. Disease hallmarks and biomarkers 18. Disease clusters 19. Disease co-morbidities 20. Free radical attack on DA 21. Free radical attack on proteins 22. Free radical attack on lipophilic cell membranes 23. Free radical stability factors 24. Free radical attack on mitochondria and energy production 25. Immune System role 26. Obesity-oxidative stress-disease triangle: Impact of obesity oxidative stress and disease 27. Acute versus chronic oxidative stress 28. Age and late onset disease 29. Total oxidative stress III. Oxidative Stress Index and Its Applications 30. Oxidative stress index and its premise 31. Predicting likelihood of disease onset 32. Identifying primary causes of specific diseases 33. Oxidative Stress Index as a public health survey instrument 34. Adverse drug reaction prediction 35. Predicting severity of COVID-19 and other diseases 36. Oxidative Stress Index as a virtual diagnostic tool 37. Disease prevention 38. Future applications
Subject Areas: The environment [RN], Medical toxicology [MMGT], Public health & preventive medicine [MBN]
