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Oxidative Stress and Antioxidant Protection
The Science of Free Radical Biology and Disease
Donald Armstrong (Edited by), D Armstrong (Author), Robert D. Stratton (Edited by)
9781118832486, Wiley
Hardback, published 25 March 2016
600 pages
25.2 x 17.8 x 3.3 cm, 1.084 kg
Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
List of Contributors ix Special Recognition xiii Foreword xv Preface xvii Section 1: Introduction 1 Introduction to Free Radicals, Inflammation, and Recycling 3 2 Diagnostic Imaging and Differential Diagnosis 11 Section 2: Clinical Correlations on Acute and Chronic Diseases 3 Free Radicals: Their Role in Brain Function and Dysfunction 23 4 Mediators of Neuroinflammation 39 5 Oxidative and Nitrative Stress in Schizophrenia 57 6 The Effects of Hypoxia, Hyperoxia, and Oxygen Fluctuations on Oxidative Signaling in the Preterm Infant and on Retinopathy of Prematurity 77 7 Oxidative Damage in the Retina 93 8 The Role of Oxidative Stress in Hearing Loss 115 9 Disorders of Children 133 10 Oxidative Stress in Oral Cavity: Interplay between Reactive Oxygen Species and Antioxidants in Health, Inflammation, and Cancer 155 11 Oxidative Stress and the Skin 167 12 Oxidative Stress in Osteoarticular Diseases 183 13 Gene Therapy to Reduce Joint Inflammation in Horses 193 14 Muscle and Oxidative Stress 205 15 Role of Oxidants and Antioxidants in Male Reproduction 221 16 Role of Oxidants and Antioxidants in Female Reproduction 253 17 Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Diseases 281 18 Oxidative Stress and Antioxidant Imbalance: Respiratory Disorders 307 19 Oxidative Stress and Type 1 Diabetes 319 20 Metabolic Syndrome, Inflammation, and Reactive Oxygen Species in Children and Adults, 329 21 Oxidative Stress in Chronic Pancreatitis 339 22 Wound Healing and Hyperbaric Oxygen Therapy Physiology: Oxidative Damage and Antioxidant Imbalance 347 23 Radiobiology and Radiotherapy 357 24 Chemotherapy-Mediated Pain and Peripheral Neuropathy: Impact of Oxidative Stress and Inflammation 367 25 Grape Polyphenol-rich Products with Antioxidant and Anti-inflammatory Properties 389 26 Isotonic Oligomeric Proanthocyanidins 403 27 Superoxide Dismutase Mimics and Other Redox-active Therapeutics 415 28 Herbal Medicine: Past, Present, and Future with Emphasis on the Use of Some Common Species 471 29 Ayurvedic Perspective on Oxidative Stress Management 483 30 Clinical Trials and Antioxidant Outcomes 493 31 Statistical Approaches to Make Decisions in Clinical Experiments 507 Index 561
Donald Armstrong
Robert D. Stratton
Natan Gadoth
Rajiv Tikamdas, Ping Zhang, and Bin Liu
Anna Dietrich-Muszalska
M. Elizabeth Hartnett
Robert D. Stratton
Colleen G. Le Prell and Josef M. Miller
Hirokazu Tsukahara and Masato Yashiro
Maurizio Battino, Maria Greabu and Bogdan Calenic
Christina L. Mitchell
María José Alcaraz, Sergio Portal-Núñez, Juan A. Ardura and Pedro Esbrit
Patrick Colahan, Rachael Watson, and Steve Ghivizzani
Reza Ghiasvand and Mitra Hariri
Ashok Agarwal, Hanna Tadros, Aaron Panicker and Eva Tvrdá
Ashok Agarwal, Hanna Tadros and Eva Tvrdá
Fatemeh Sharifpanah and Heinrich Sauer
Surinder K. Jindal
Chao Liu, Clayton E. Mathews, and Jing Chen
William E. Winter and Janet H. Silverstein
Shweta Singh and Bechan Sharma
James R. Wilcox and D. Scott Covington
Justin Wray and Judith Lightsey
Hassan A.N. El-Fawal, Robert Rembisz, Ryyan Alobaidi, and Shaker A. Mousa
Eduarda Fernandes, Marisa Freitas, Renan C. Chisté, Elena Falqué, and Herminia Domínguez
Hanbo Hu and Donald Armstrong
Ines Batinic-Haberle and Artak Tovmasyan
Aneela Afzal and Mohammad Afzal
Priyanka M. Jadhav
Carlos Palacio and Arshag D. Mooradian
Albert Vexler and Xiwei Chen
Subject Areas: Biology, life sciences [PS]
