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Organoids and Mini-Organs
The first book to provide protocols for organoids and their further applications in clinical research
Jamie A. Davies (Edited by), Melanie Lawrence (Edited by)
9780128126363, Elsevier Science
Paperback, published 18 May 2018
284 pages
23.4 x 19 x 1.9 cm, 0.59 kg
Organs and Mini-Organs combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved.
PART I INTRODUCTION 1. Organoids and mini-organs: Introduction, history, and potential PART II CONSTRUCTING ORGANOIDS 2. Elements of organoid design 3. Intestinal organoids: Mini-guts grown in the laboratory 4. Three-dimensional breast culture models 5. Prostate organoids: Directed differentiation from embryonic stem cells 6. Kidney organoids 7. Spontaneous self-assembly of liver organoids from differentiated human cells 8. Cerebral organoids: Building brains from stem cells 9. From organoids to mini-organs: A case study in the kidney PART III APPLICATIONS OF ORGANOIDS 10. Intestinal organoids: A model for biomedical and nutritional research 11. A three-dimensional neurosphere system using human stem cells for nanotoxicology studies 12. Organoids for modeling kidney disease 13. Intestinal organoids in studying host2bacterial interactions 14. Four challenges for organoid engineers
Subject Areas: Developmental biology [PSC]
