Organofluorine Compounds in Biology and Medicine

Covers the synthesis and biochemical and therapeutic applications of organofluorine compounds, making it an essential source for researchers interested in fluorine chemistry and its biomedical applications

V Prakash Reddy (Author)

9780444537485

Hardback, published 28 January 2015

330 pages, 20 illustrations
22.9 x 15.1 x 2.4 cm, 0.62 kg

Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

1. Introduction: General aspects of organofluorine compounds2. C-F bond strengths3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies4. Effect of fluorine on the acidity and basicity5. Effect of fluorine on the metabolic stability6. Effect of fluorine on the bioavailability7. Positron emission tomography (PET) tracers8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms9. Summary and outlook

Subject Areas: Biotechnology [TCB], Biochemistry [PSB], Organic chemistry [PNN], Pharmacology [MMG]