Organic Chemistry Concepts and Applications for Medicinal Chemistry

This accessible primer reviews how organic molecules are put together, their 3D structure and properties, and the relationship between chemical structure and medicinal activity.

Joseph E. Rice (Author)

9780128007396

Paperback, published 26 June 2014

224 pages, 130 illustrations
22.9 x 15.1 x 1.5 cm, 0.36 kg

Approx.224 pages

1. Bonding in Organic Compounds a. Atomic Orbitals b. Hybrid Orbitals c. Resonance d. Aromaticity2. The Three-Dimensional Structure of Organic Compounds a. Isomers b. Stereoisomerism at Saturated Centers c. Prochirality d. Conformations3. Functional Groups a. Common Functional Groups b. The Electronic Effects of Functional Groups4. Acids and Bases a. Bronsted-Lowry Acids and Bases b. Ionization c. Estimating Acid/Base Strength d. Lewis Acids and Bases5. Partition Coefficients a. What is a Partition Coefficient? b. Effect of Structure on Partition Coefficients6. The Nomenclature of Cyclic and Polycyclic Compounds a. Common Heterocycles b. Fused-Ring Systems c. Substituents and Saturation d. Bridged-Rings e. Spiro-Rings f. Special Classes of Compounds i. Steroids ii. Prostaglandins iii. Morphinans7. Drug Metabolism a. Phase I – Oxidative Processes b. Phase I – Reductions c. Phase I – Hydrolysis d. Phase II – Conjugation e. Miscellaneous Phase II Processes

Subject Areas: Organic chemistry [PNN]