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Organ Repair and Regeneration
Preserving Organs in the Regenerative Medicine Era
A one-of-a-kind publication based on pioneering and unique research efforts in the field of organ transplantation
Giuseppe Orlando (Edited by), Shaf Keshavjee (Edited by)
9780128194515
Paperback, published 15 January 2021
304 pages, 50 illustrations (25 in full color)
23.4 x 19 x 2 cm, 0.66 kg
"The book is written in a comprehensive, yet digestible manner and meets its objectives. It is a unique and needed contribution to the field." --© Doody’s Review Service, 2021, Kelly M. Collins, MD(Henry Ford Hospital) reviewer, expert opinion "This book demonstrates the merging of regenerative medicine and organ transplantation. Key Features: Covers all aspects of organ preservation, repair and regeneration; Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ; Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine." --Anticancer Research "This is the latest in a series of textbooks published by Academic Press/Elsevier, edited or co-edited by Dr. Giuseppe Orlando, in the broad field of organ transplantation and covering all aspects of organ regeneration, from technological advances in organ preservation and reperfusion to regenerative medicine [1–3]. Orlando is a kidney and pancreas transplant surgeon from Wake Forest University, a unique environment in which a strong transplant programme coexists with a world-renowned institute of regenerative medicine, led by Dr. Anthony Atala. Organ Repair and Regeneration is a 289-page book co-edited by Orlando and Dr. Shaf Keshavjee, who has been a pioneer in the reconditioning of marginal lung grafts. The book is divided into 14 chapters written by authors from North America, Europe and Australia. In his foreword to this book, Dr. Atala sets the stage for what readers can expect from this book: ‘...we have developed a surrogate field of science called ‘organ preservation’ that –to the editors of this book – represents the most formidable platform nowadays for the application of regenerative medicine technologies in transplant medicine’ [4]. The book is divided into 14 chapters that can each be read as an independent review article. It is introduced by a chapter describing the concepts and molecular mechanisms of ischaemia-reperfusion injury that will be a reference for all further chapters of the book." --Transplant International
Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation.
1. Ischemia-reperfusion injury
JENNIFER LI, NATASHA M. ROGERS, AND WAYNE J. HAWTHORNE
2. Machine perfusion for donor organ repair: from vision to everyday clinical practice
MASATO FUJIYOSHI, VINCENT E. DE MEIJER, AND ROBERT J. PORTE
3. Assessing and reconditioning kidneys using normothermic machine perfusion
FANOURIOS GEORGIADES, SARAH A. HOSGOOD, AND MICHAEL L. NICHOLSON
4. Autologous cells for renal allograft repair
MARK CLANCY
5. Repairing organs with MSC
LAUREN BRASILE
6. Resuscitation of the pancreas: whole organ and islet cell technologies into the machine era
AHMER HAMEED AND WAYNE J. HAWTHORNE
7. Assessment of extended criteria liver grafts during machine perfusion. How far can we go?
LAURA IOANA MAZILESCU AND MARKUS SELZNER
8. RNA interference in organ transplantation: next-generation medicine?
ISABEL M.A. BR€UGGENWIRTH AND PAULO N. MARTINS
9. Repairing cardiac allografts on ex situ perfusion devices
S.E. SCHEUER, P.S. MACDONALD, AND K. DHITAL
10. Repairing cardiac allografts in situ
OSCAR ZOU, SIMON MESSER, AND STEPHEN LARGE
11. Steatotic livers for transplantation: improving utilization of a prevalent resource through organ repair
SIAVASH RAIGANI, AYLIN ACUN, BASAK UYGUN, KORKUT UYGUN, AND HEIDI YEH
12. Implementing the vision: the organ repair center
SHAF KESHAVJEE
13. Mitochondria transplantation in organ damage and repair
ANDREA ROSSI, PAOLO PORPORATO, AND BENEDETTA BUSSOLATI
14. How the transplant landscape is changing in the regenerative medicine era
PAULA A. GRISALES, JUSTINE M. AZIZ, SEAN M. MUIR, DOMENICA I. MARINO, CATHERINE LA POINTE, AMISH ASTHANA, AND GIUSEPPE ORLANDO
Subject Areas: Life sciences: general issues [PSA]
