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Organ-on-a-chip
Engineered Microenvironments for Safety and Efficacy Testing
A comprehensive overview of organ on a chip technology, why it can be useful, and the type of systems currently available
Julia Hoeng (Edited by), David Bovard (Edited by), Manuel C. Peitsch (Edited by)
9780128172025, Elsevier Science
Paperback, published 11 November 2019
546 pages, Approx. 150 illustrations (150 in full color)
23.4 x 19 x 3.4 cm, 1.04 kg
"As a carnivore, when reading this text, I wondered if lessons learned from current attempts to “grow? meat could be applied to some of the work herein. (See, for example, “The race to make cell grown meats mainstream,? Popular Mechanics, July/August 2020, pp. 44–51.) As a (retired) design instructor, having had the experience of having had students working on organ-on-a-chip devices for their senior projects, I find this book to be very up to date and a good overview of the field. As a reviewer, I recommend this text for use in introducing new investigators and entrepreneurs to this field of applied work in physiology and toxicology." --IEEE EMBS PULSE Magazine
Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.
1. Need for alternative testing methods and opportunities for organ-on-a-chip systems 2. Cell sources and methods for producing organotypic in vitro human tissue models 3. Organs-on-a-chip engineering Part I Organ-on-a-chip platforms to model disease pathogenesis 4. Lung-on-a-chip platforms for modeling disease pathogenesis 5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease 6. Brain-on-a-chip systems for modeling disease pathogenesis 7. Kidney-on-a-chip 8. Heart-on-a-chip 9. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping 10. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment 11. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems Part II Multi-organs-on-a-chip platforms to mimic humans physiology 12. Design and engineering of multiorgan systems 13. 8.b. Human body-on-a-chip systems 14. Automation and opportunities for industry scale-up of microphysiological systems 15. How to build your multiorgan-on-a-chip system: a case study
Subject Areas: Engineering: general [TBC]
