• Optogenetics; Tools for Controlling and Monitoring Neuronal Activity (Hardback) 9780444594266
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Optogenetics
Tools for Controlling and Monitoring Neuronal Activity

Reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology

Thomas Knopfel (Volume editor), Edward S. Boyden (Volume editor)

9780444594266, Elsevier Science

Hardback, published 1 March 2012

288 pages
23.4 x 19 x 2.3 cm, 0.75 kg

Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology.

These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.

  1. A comprehensive concept of optogenetics

    2. Guillaume P. Dugué, Walther Akemann, and Thomas Knöpfel

  2. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants

    3. John Y. Lin

  3. Genetically encoded molecular tools for light-driven silencing of targeted neurons

    4. Brian Y. Chow, Xue Han, and Edward S. Boyden

  4. Genetically encoded probes for optical imaging of brain electrical activity

    5. Amelie Perron, Walther Akemann, Hiroki Mutoh and Thomas Knöpfel

  5. Neural activity imaging with genetically encoded calcium indicators

    6. Lin Tian, Jasper Akerboom, Eric R. Schreiter, and Loren L. Looger

  6. Manipulating cellular processes using optical control of protein-protein interactions

    7. Chandra L. Tucker

  7. Two-photon optogenetics

    8. Dan Oron, Eirini Papagiakoumou, F. Anselmi, and Valentina Emiliani

  8. Zebrafish as an appealing model for optogenetic studies

    9. Joshua Simmich, Eric Staykov, and Ethan Scott

  9. Genetic targeting of specific neuronal cell types in the cerebral cortex

    10. Alan Urban, and Jean Rossier

  10. Mouse transgenic approaches in optogenetics

    11. Hongkui Zeng, and Linda Madisen

  11. Optogenetics in the nonhuman primate

    12. Xue Han

  12. Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain Mathew Tantama, Yin Pun Hung,and Gary Yellen

Subject Areas: Neurosciences [PSAN], Genetics [non-medical PSAK], Mathematics & science [P], Neurology & clinical neurophysiology [MJN]
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