Opioids

A volume exploring the physiological, behavioral and neurobiological study of opioid addiction

George F. Koob (Author), Michael A. Arends (Author), Mandy L McCracken (Author), Michel Le Moal (Author)

9780128169889, Elsevier Science

Paperback, published 1 June 2023

424 pages
23.5 x 19 x 2.7 cm, 0.45 kg

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation.

1. Definitions
2. History of opioid use
3. Mechanism of action: endogenous opioid system
4. Physiological effects
5. Behavioral effects
6. Pharmacokinetics
7. Behavioral mechanism of action
8. Medical use, abuse, and addiction
9. Neurobiological effects
10. Summary

Subject Areas: Neurosciences [PSAN], Physiological & neuro-psychology, biopsychology [JMM]