• Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors (Hardback) 9780123945877
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Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Written by research experts, this volume of Progress in Molecular Biology and Translational Science focuses on current science surrounding G protein-coupled receptors and applications

Terry P. Kenakin (Volume editor)

9780123945877, Elsevier Science

Hardback, published 18 April 2013

488 pages
22.9 x 15.1 x 2.9 cm, 0.71 kg

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

  1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
    2.

    Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

  2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders

    3. Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

  3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery

    4. Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

  4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design

    5. Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

  5. GPCRs in Stem Cell Function

    6. Van A. Doze and Dianne M. Perez

  6. Application of Receptor Theory to Allosteric Modulation of Receptors

    7. David A. Hall

  7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors

    8. Frederick J. Ehlert

  8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors

    9. Jesús Giraldo

  9. Chemokine Receptor Oligomerization and Allostery

    10. Bryan Stephens and Tracy M. Handel

  10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

Subject Areas: Molecular biology [PSD], Biochemistry [PSB], Cellular physiology [MFGC]
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